Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern
Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern
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Omega-3 PUFA 通过形成保护性类二十烷酸模式减轻小鼠心肌梗死损伤
DOI：
10.1016/j.prostaglandins.2018.09.002
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发表时间：
2018-11-01
影响因子：
2.9
通讯作者：
Zhang, Xu
中科院分区：
文献类型：
--
作者：
Fang, Xuan;Cai, Wenbin;Zhang, Xu
补充 Omega-3 多不饱和脂肪酸 (n-3 PUFA) 是预防心血管疾病的推荐方法，但其预防心肌梗死 (MI) 损伤的机制尚不完全清楚。类二十烷酸代谢组学表明，接受 MI 手术的小鼠血浆中存在异常的类二十烷酸谱。手术后19,20-EDP、17,18-EEQ、14,15-EET和9,10-EpOME降低，PGE(2)升高。富含 N-3 PUFA 的饮食或 Fat-1 转基因将类二十烷酸谱转变为 n-3 PUFA 占主导地位，并减轻了心肌梗塞损伤。多元逻辑回归分析表明，MI 损伤程度与类二十烷酸模式相关，该模式由三种酶途径中的 n-3 和 n-6 PUFA 衍生的类二十烷酸组成。这些结果表明 n-3 PUFA 对 MI 的益处是协同实现的。
Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation is a recommended preventive approach against cardiovascular diseases, but its mechanism of protection against myocardial infarction (MI) injury is not fully understood. Eicosanoid metabolomics demonstrated an abnormal eicosanoid profile was in the plasma of mice receiving MI surgery. 19,20-EDP, 17,18-EEQ, 14,15-EET and 9,10-EpOME were decreased, and PGE(2) was increased by the surgery. N-3 PUFA-rich diets feeding or transgene of Fat-1 shifted the eicosanoid profile to an n-3 PUFA dominant style and attenuated the myocardial infarction injury. Multiple logistic regression analysis suggested the degree of MI injury was related with an eicosanoid pattern, composed by eicosanoids derived from both n-3 and n-6 PUFA in the three enzymatic pathways. These results suggested the benefits of n-3 PUFA on MI was achieved synergistically.