Bronchiolitis obliterans syndrome in lung transplant recipients: Correlation of computed tomography findings with bronchiolitis obliterans syndrome stage
Bronchiolitis obliterans syndrome in lung transplant recipients: Correlation of computed tomography findings with bronchiolitis obliterans syndrome stage
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DOI：
10.1097/00005382-200304000-00003
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发表时间：
2003-04-01
影响因子：
3.3
通讯作者：
McAdams, HP
中科院分区：
文献类型：
--
作者：
Choi, YW;Rossi, SE;McAdams, HP
本研究的目的是将肺移植受者的闭塞性细支气管炎综合征（BOS）的计算机断层扫描（CT）结果与呼吸功能障碍的严重程度相关联。对44例BOS移植受者（17例双侧，27例单侧）进行的89例常规和61例薄层CT扫描进行了回顾性分析，以了解马赛克衰减、支气管扩张程度、支气管增厚、中央和外周支气管扩张、粘液堵塞和空气潴留。双肺和单肺移植受者的常规和薄层CT扫描结果与BOS分期相关。在双侧肺移植受者中，BOS分期与支气管扩张程度之间存在显著相关性，尽管相关性较弱支气管壁增厚（P < 0.01）（P = 0.01），外周支气管扩张常规CT显示支气管壁增厚（P = 0.01）和马赛克衰减（P = 0.01）;薄层CT显示支气管壁增厚（P = 0.01）和马赛克衰减（P = 0.03）。在单肺受体中，BOS分期仅与常规CT扫描发现的中心性支气管扩张相关（P = 0.02）。在单肺或双侧肺移植受者中，未发现空气潴留程度与BOS分期之间存在相关性。CT表现是BOS肺移植受者气流阻塞的相对较差的指标，尤其是那些因肺气肿而进行单肺移植的受者。
The purpose of this study was to correlate the extent of computed tomographic (CT) findings with the severity of respiratory dysfunction in lung transplant recipients with bronchiolitis obliterans syndrome (BOS). Eighty-nine conventional and 61 thin-section CT scans performed in 44 transplant recipients (17 bilateral, 27 single) with BOS were reviewed for mosaic attenuation, degree of bronchial dilation, bronchial thickening, central and peripheral bronchiectasis, mucus plugging, and air trapping. Findings on conventional and thin-section CT scans were correlated with BOS stage for bilateral and single-lung transplant recipients. In bilateral-lung recipients, a significant correlation existed, although weak, between BOS stage and findings of degree of bronchial dilation (P < 0.01), bronchial wall thickening (P = 0.01), peripheral bronchiectasis (P = 0.01), and mosaic attenuation (P = 0.01) on conventional CT; and bronchial wall thickening (P = 0.01) and mosaic attenuation (P = 0.03) on thin-section CT. In single-lung recipients, BOS stage correlated only with the finding of central bronchiectasis (P = 0.02) on conventional CT scans. No correlation was found between the extent of air trapping and BOS stage in either single- or bilaterallung transplant recipients. CT findings are relatively poor indices of airflow obstruction in lung transplant recipients with BOS, particularly in those with single-lung transplants for emphysema.