Membranous Nephropathy: From Research Bench to Personalized Care.
Membranous Nephropathy: From Research Bench to Personalized Care.
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膜性肾病：从实验室研究到个性化护理。
DOI：
10.3390/jcm10061205
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发表时间：
2021-03-14
影响因子：
3.9
通讯作者：
Mucha K
中科院分区：
文献类型：
--
作者：
Moszczuk B;Kiryluk K;Pączek L;Mucha K
Membranous nephropathy is a glomerulopathy that causes nephrotic syndrome and, in at least a third of cases, lasting end-stage kidney disease (ESKD). It is also a rare case of revolutionary changes in our understanding of the disease, that translates from scientific findings to real diagnosis and treatment recommendations in less than ten years. In this review we present: (1) a short history and traditional approach to patients with membranous nephropathy, (2) current recommendations and treatment options that have emerged in recent years, (3) findings of new studies, with a particular focus on serological/immunological methods, genomic and proteomic studies, still requiring validation. With further development in this field, membranous nephropathy may become one of the first nephrological conditions that apply a truly personalized approach with the omission of invasive measures such as kidney biopsy.
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