Molecular genetics of the early stages of germ cell differentiation during Drosophila oogenesis.
Molecular genetics of the early stages of germ cell differentiation during Drosophila oogenesis.
复制标题
果蝇卵子发生过程中生殖细胞分化早期阶段的分子遗传学。
DOI：
10.1002/9780470514573.ch12
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Christerson,L
中科院分区：
文献类型：
--
作者：
McKearin,D;Christerson,L
Germ cells frequently develop in syncytial clusters. We are using molecular genetic approaches to the formation of these clusters inDrosophilaas a paradigm for cellular differentiation. The genes described in this paper act during an initial step of cluster formation (bag‐of‐marblesgene [bam]) and near the end of syncytial divisions (orb gene). The results presented suggest that thebamgene product is required for the four incomplete cytokineses that characterize the initial stages of cluster formation. Theorbgene, previously identified as an ovarian‐specific cDNA which predicts a new member of the RNA‐recognition motif family of RNA‐binding proteins, is required for both early and late stages of oogenesis. Strongorballeles arrest egg development at the time of nurse cell‐oocyte cyst formation; weak alleles disrupt formation of the anteroposterior and dorsoventral axes within the oocyte during late oogenesis. We postulate that Orb is a constituent of cytoplasmic multiprotein complexes which deliver RNA molecules to specific addresses within the oocyte.
