Circadian dynamics in measures of cortical excitation and inhibition balance.
Circadian dynamics in measures of cortical excitation and inhibition balance.
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DOI：
10.1038/srep33661
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发表时间：
2016-09-21
影响因子：
4.6
通讯作者：
Vandewalle G
中科院分区：
文献类型：
--
作者：
Chellappa SL;Gaggioni G;Ly JQ;Papachilleos S;Borsu C;Brzozowski A;Rosanova M;Sarasso S;Luxen A;Middleton B;Archer SN;Dijk DJ;Massimini M;Maquet P;Phillips C;Moran RJ;Vandewalle G
最近，几种神经精神和神经系统疾病被描述为皮层网络内兴奋与抑制失衡的“最终共同通路”引起的功能障碍。然而，皮层E/I比率的调节如何受到睡眠和昼夜节律的影响，仍有待确定。在这里，我们解决了这个问题，通过分析TMS诱发的反应记录在29小时的睡眠剥夺协议在年轻和健康的志愿者。在额叶皮层的TMS诱发反应的频谱分析显示，非线性变化的γ波段诱发振荡，兼容的昼夜节律定时抑制性interneuron活动的影响。基于动态因果建模框架内的神经质量建模，对细胞间兴奋性和抑制性连接性以及GABA/谷氨酸受体时间常数进行了计算机模拟推断，进一步表明兴奋/抑制平衡受到强烈的昼夜节律影响。这些结果表明，昼夜变化的EEG频谱特性，兴奋性/抑制性连接和GABA/谷氨酸受体功能的测量可以支持在正常清醒的一天，但也在夜间清醒的认知性能的维护。更一般地说，这些发现表明，皮质兴奋/抑制平衡的日常调节缓慢，这取决于昼夜节律和先前的睡眠-觉醒历史。
Several neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a ‘final common pathway’ of imbalanced excitation to inhibition within cortical networks. How the regulation of a cortical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established. Here we addressed this issue through the analyses of TMS-evoked responses recorded over a 29 h sleep deprivation protocol conducted in young and healthy volunteers. Spectral analyses of TMS-evoked responses in frontal cortex revealed non-linear changes in gamma band evoked oscillations, compatible with an influence of circadian timing on inhibitory interneuron activity. In silico inferences of cell-to-cell excitatory and inhibitory connectivity and GABA/Glutamate receptor time constant based on neural mass modeling within the Dynamic causal modeling framework, further suggested excitation/inhibition balance was under a strong circadian influence. These results indicate that circadian changes in EEG spectral properties, in measure of excitatory/inhibitory connectivity and in GABA/glutamate receptor function could support the maintenance of cognitive performance during a normal waking day, but also during overnight wakefulness. More generally, these findings demonstrate a slow daily regulation of cortical excitation/inhibition balance, which depends on circadian-timing and prior sleep-wake history.