Regional age-dependent effects of hemineodecortication upon contralateral neocortical thickness: comparison with other measures of cortical size.
Regional age-dependent effects of hemineodecortication upon contralateral neocortical thickness: comparison with other measures of cortical size.
复制标题
半侧皮质去皮质对对侧新皮质厚度的区域年龄依赖性影响：与其他皮质尺寸测量方法的比较。
DOI：
10.1159/000017378
复制
发表时间：
1999
影响因子：
2.9
通讯作者：
Villablanca,JR
中科院分区：
文献类型：
--
作者：
Schmanke,TD;Villablanca,JR
这项研究调查了猫半皮质去皮质后区域新皮质厚度随年龄变化的变化，并将结果与之前报道的体积和横截面数据进行了比较。受试者在出生后 (P) P10、P30、P60 或成年后持续进行半侧皮质去皮质。使用主脑沟的确定部位进行测量，对沿着 20 个立体定位冠状前后 (AP) 平面的 115 个部位的新皮质厚度进行量化。分析表明，与 (a) AP +14 时的 P30、P60 和对照组、(b) 沿着 AP +9 至 AP +3 范围的 7 个平面上的 P30 组以及 (c) AP +6 时的 P10 和 P60 组相比，成人病变的厚度值显着较低。 P10 和 P30 组在 AP +10（顶叶和颞叶皮质）后面的选定冠状平面上表现出比对照组明显更厚的新皮质。通过脑沟进行分析时，结果再次反映出早期病变猫的显着优势，在检查的 8 个脑沟中，有 4 个发现了明显更厚的皮质。同样，与对照猫（压部、十字沟）相比，早期病变受试者也发现了显着的优势。总体而言，显着影响的范围（从 AP +14 到 AP 0）和均值方向表明，新皮质厚度存在显着的、年龄依赖性（P10-P60）区域保留，峰值效应出现在 P30。我们的结论是：（a）新皮质厚度存在区域性保留/增加，表明在幼猫（P10-P60）中，离散的皮质区域选择性地参与了对半皮质去皮质后结构萎缩的抵抗；（b）使用目前的厚度测量，我们之前的研究中发现的新皮质体积的整体损失并不明显。建议在评估人类病理学（即半球切除术、难治性癫痫）或动物模型中对新皮质的形态学影响时，必须考虑这两种测量结果。
This study investigated age-dependent changes in regional neocortical thickness after hemineodecortication in cats and compared the results to previously reported volumetric and cross-sectional data. Subjects sustained hemineodecortication on postnatal days (P) P10, P30, P60 or in adulthood. Neocortical thickness was quantified at 115 sites along 20 stereotaxic coronal anterior-posterior (AP) planes using defined sites of the main cerebral sulci for the measurements. The analysis established significantly lower thickness values for adult-lesioned as compared to (a) P30, P60 and control groups at AP +14, (b) P30 group at 7 planes along a range of AP +9 to AP +3, and (c) P10 and P60 groups at AP +6. Both the P10 and the P30 groups presented a significantly thicker neocortex than controls at select coronal planes clustering behind AP +10 (parietal and temporal cortices). When analyzed by sulcus, results once again reflected significant advantages for the early-lesioned cats with a significantly thicker cortex found at 4 of the 8 sulci examined. Again, significant advantages were also discovered for early-lesion subjects compared with control cats (splenial, cruciate sulci). Overall, the range of significant effects (from AP +14 to AP 0) and the direction of the means suggested that there was a significant, age-dependent (P10–P60), regional sparing of neocortical thickness with a peak effect occurring at P30. We concluded that: (a) there was a regional sparing/increase of neocortical thickness suggesting that discrete cortical areas are selectively involved in the resistance to structural atrophy following hemineodecortication in young cats (P10–P60) and (b) thegloballoss of neocortexvolumefound in our previous study was not apparent using the present thickness measurement. It is suggested that both of these measurements must be taken into account when assessing morphological effects upon the neocortex either in human pathology (i.e. hemispherectomy, intractable epilepsy) or in animal models.