Soluble guanylate cyclase contribute genetic susceptibility to essential hypertension in the Han Chinese population
Soluble guanylate cyclase contribute genetic susceptibility to essential hypertension in the Han Chinese population
复制标题
可溶性鸟苷酸环化酶导致中国汉族人群原发性高血压的遗传易感性
DOI：
10.21037/atm.2019.11.49
复制
发表时间：
2019-11-01
影响因子：
--
通讯作者：
Zhou, Chengchao
中科院分区：
文献类型：
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作者：
Chen, Yan;Zhu, Lijun;Zhou, Chengchao
背景：动物实验发现可溶性鸟苷酸环化酶（sGC）通过影响NO-sGC-CGMP信号通路在高血压（HT）的发生发展中发挥重要作用。本研究旨在评估汉族人群中sGC与原发性高血压（EH）的关系。方法：本研究纳入2012例高血压患者和2210例对照，选取GUCY1A3中的rs3806777、rs3806782、rs3796576和rs7698460，以及GUCY1B3中的rs2229202和rs1459853 6个标记单核苷酸多态性（snp）。本研究进一步评估了这6个snp与EH的关系。结果：GUCY1B3中rs1459853的A/A基因型与较高的HT风险相关，其隐性模型的优势比（OR）为1.191 （P=0.044）。在调整协变量后，相关性仍然显著。进一步的分层分析显示，非饮酒受试者的rs1459853和女性的rs7698460与EH相关。在随访研究中，rs1459853与男性和吸烟者的HT风险增加有关。在青少年中，GUCY1B3中的rs2229202与高血压前期（Pre-HT）、高血压前期（Pre-HT + HT）、高血压前期（Pre-HT + HT）存在显著相关性。调整协变量后，相关性仍然显著。在女孩中，rs3806782与HT和Pre-HT + HT显著相关。结论：总的来说，我们的研究结果表明sGC可能与EH的遗传易感性有关，并且首次在青少年中得到验证。
Background: Animal study found that soluble guanylate cyclase (sGC) plays an important role in development of hypertension (HT) by affecting the NO-sGC-CGMP signaling pathway. This study aims to evaluate the association of sGC with essential hypertension (EH) in the Han Chinese population.Methods: This case-control study included 2,012 hypertensive cases and 2,210 controls, and 6 tagging single nucleotide polymorphisms (SNPs) were selected (rs3806777, rs3806782, rs3796576 and rs7698460 in GUCY1A3, as well as rs2229202 and rs1459853 in GUCY1B3). Then the association of the six SNPs with EH was further evaluated in this study.Results: The results indicated that the A/A genotype of rs1459853 in GUCY1B3 was associated with higher HT risk, and the odds ratio (OR) of its recessive model was 1.191 (P=0.044). After adjusting for covariates, the association was still significant. Further stratification analyses showed that rs1459853 in non-drinking subjects and rs7698460 in women were associated with EH. In the follow-up study, rs1459853 were related to increased HT risk in men and smoker subjects. In adolescents, rs2229202 that in GUCY1B3 had significant association with prehypertension (Pre-HT), HT, and prehypertension with hypertension (Pre-HT + HT). After adjusted for covariates, the association was remaining significant. And in girls, rs3806782 was significantly connected with HT and Pre-HT + HT.Conclusions: Overall, our findings suggest that sGC may contribute to the genetic susceptibility to EH, and it was validated for the first time in adolescents.