HERPESVIRUS HOMINIS - ISOLATION FROM HUMAN TRIGEMINAL GANGLION
HERPESVIRUS HOMINIS - ISOLATION FROM HUMAN TRIGEMINAL GANGLION
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DOI：
10.1126/science.178.4058.306
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
RABSON, AS
中科院分区：
文献类型：
--
作者：
BASTIAN, FO;TRALKA, TS;RABSON, AS
人型疱疹病毒是从 22 名无活动性疱疹病临床证据的患者中的 1 名尸检获得的三叉神经节中分离出来的，以及从一名死于腹部带状疱疹、肺巨细胞包涵体病和可能的口腔单纯疱疹的恶性淋巴瘤患者身上获得的。通过将神经节外植体与单层 Vero 绿猴肾细胞共培养来分离病毒，需要培养 3 周才能出现明显的病毒细胞病变效应。这些观察结果支持这样的观点：感觉神经节的潜伏感染可能是人类复发性疱疹病的病毒来源。
Herpesvirus hominiswas isolated from the trigeminal ganglion obtained at autopsy from 1 of 22 patients with no clinical evidence of active herpetic disease, and from one patient with malignant lymphoma who died with herpes zoster on the abdomen, pulmonary cytomegalic inclusion disease, and possible oral herpes simplex. Virus was isolated by cocultivation of explants of ganglion with monolayers of Vero green monkey kidney cells and required 3 weeks of culture before viral cytopathic effects were evident. These observations support the concept that latent infection of sensory ganglia may be the source of virus in recurrent herpetic disease in man.