Frequency and correlates of co-morbid psychosis and depression in Parkinson's disease.
Frequency and correlates of co-morbid psychosis and depression in Parkinson's disease.
复制标题
帕金森病共病精神病和抑郁症的频率和相关性。
DOI：
10.1016/j.parkreldis.2006.03.006
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发表时间：
2006
影响因子：
4.1
通讯作者：
Stern,MatthewB
中科院分区：
文献类型：
--
作者：
Weintraub,Daniel;Morales,KnashawnH;Duda,JohnE;Moberg,PaulJ;Stern,MatthewB
尽管精神病和抑郁症在帕金森病 (PD) 中都很常见，但尚不清楚这两种疾病之间是否存在关联。根据综合精神病学评估，130名PD患者被分为四组：（1）没有抑郁或精神病（47.7％）； (2) 仅精神病（16.2%）； （3）仅有抑郁症（26.2%）； （4）精神病和抑郁症（10.0%）。精神病和抑郁症共病的发生频率并不比偶然预期的高（P=.77）。精神病与多巴胺激动剂的使用（P=.02）、抑郁伴轻度认知障碍（P=.03）以及它们与较高的每日左旋多巴剂量同时发生（P<.01）有关。这些结果表明帕金森病中的精神病和抑郁症是不同的神经行为障碍。
Though both psychosis and depression are common in Parkinson's disease (PD), it is not clear if an association between the two disorders exists. One hundred and thirty PD patients were divided into four groups based on a comprehensive psychiatric assessment: (1) no depression or psychosis (47.7%); (2) psychosis only (16.2%); (3) depression only (26.2%); and (4) psychosis and depression (10.0%). Co-morbid psychosis and depression did not occur more frequently than expected by chance (P=.77). Psychosis was associated with dopamine agonist use (P=.02), depression with mild-cognitive impairment (P=.03), and their co-occurrence with higher daily levodopa dosages (P<.01). These results suggest that psychosis and depression in PD are distinct neurobehavioral disorders.