Chromatin evolution and molecular drive in speciation.
Chromatin evolution and molecular drive in speciation.
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DOI：
10.1155/2012/301894
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Sawamura K
中科院分区：
文献类型：
--
作者：
Sawamura K
杂种不育或不可生存是否存在生物学共性？最近，主要在果蝇中鉴定了大约十几个“物种形成基因”，这些基因的生物学功能正在揭示分子共性。杂交不育和不存活的主要情况似乎是由染色质进化和物种形成中的分子驱动造成的。异染色质内的重复卫星DNA，特别是在着丝粒处，通过分子驱动机制（减数分裂和着丝粒）快速进化。因此，染色质结合蛋白也必须快速进化以保持结合能力。因此，染色质结合蛋白可能无法与杂种中另一个物种的染色体相互作用，导致杂种不育和不可存活。
Are there biological generalities that underlie hybrid sterility or inviability? Recently, around a dozen “speciation genes” have been identified mainly in Drosophila, and the biological functions of these genes are revealing molecular generalities. Major cases of hybrid sterility and inviability seem to result from chromatin evolution and molecular drive in speciation. Repetitive satellite DNAs within heterochromatin, especially at centromeres, evolve rapidly through molecular drive mechanisms (both meiotic and centromeric). Chromatin-binding proteins, therefore, must also evolve rapidly to maintain binding capability. As a result, chromatin binding proteins may not be able to interact with chromosomes from another species in a hybrid, causing hybrid sterility and inviability.