ΔNp63 is upregulated during salivary gland regeneration following duct ligation and irradiation in mice
ΔNp63 is upregulated during salivary gland regeneration following duct ligation and irradiation in mice
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DOI：
10.1002/1873-3468.13896
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发表时间：
2020-08-18
期刊：
影响因子：
3.5
通讯作者：
Sakai, Takayoshi
中科院分区：
文献类型：
--
作者：
Ikai, Kazuki;Sakai, Manabu;Sakai, Takayoshi
转录因子p63是p53家族的一个成员，在上皮组织的发育、稳态和再生中具有重要功能。然而，p63在外分泌腺，包括唾液腺（SGs）的再生中的作用尚未得到充分研究。我们研究了p63在导管结扎和辐射诱导的SG再生中的表达。p63亚型Delta Np63表达增加，与角蛋白5阳性细胞共定位，为肌上皮细胞。此外，Delta Np63的表达受FGF7刺激通过38 MAPK磷酸化调节，并影响SG形态发生。这些结果表明，Delta Np63是SG再生所必需的，并且可能是再生治疗的新靶点。
The transcription factor p63, a component of the p53 family, has important functions in development, homeostasis, and regeneration of epithelial tissues. However, the role of p63 in the regeneration of exocrine glands, including the salivary glands (SGs), has not been fully investigated. We investigated p63 expression in SG regeneration induced by duct ligation and irradiation. The expression of Delta Np63, a p63 isoform, increased and was colocalized with keratin 5 positive cells were myoepithelial cells. Furthermore, Delta Np63 expression was regulated by FGF7 stimulationviap38 MAPK phosphorylation and affected SG morphogenesis. These results suggest that Delta Np63 is essential for SG regeneration and may be a new target for regenerative treatment.