Local positive feedback regulation determines cell shape in root hair cells
Local positive feedback regulation determines cell shape in root hair cells
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DOI：
10.1126/science.1152505
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发表时间：
2008-02-29
期刊：
影响因子：
56.9
通讯作者：
Dolan, Liam
中科院分区：
文献类型：
--
作者：
Takeda, Seiji;Gapper, Catherine;Dolan, Liam
在所有生物的细胞形态发生过程中，生长位点的特化和维持受到严格调控。根毛缺陷2减少烟酰胺腺嘌呤二核苷酸磷酸（RHD 2NADPH）氧化酶衍生的活性氧（ROS）刺激拟南芥根毛生长所需的Ca 2+流入细胞质。我们发现，Ca ~（2+）反过来激活RHD_2 NADPH氧化酶，在根毛生长点产生ROS。总之，这些成分可以建立一种正反馈调节的手段，在扩大根毛细胞中保持活跃的生长部位。由于生长位点的位置和稳定性预测了植物细胞的最终形式，我们的研究结果证明了涉及RHD 2，ROS和Ca 2+的正反馈机制如何决定细胞形状。
The specification and maintenance of growth sites are tightly regulated during cell morphogenesis in all organisms. ROOT HAIR DEFECTIVE 2 reduced nicotinamide adenine dinucleotide phosphate ( RHD2 NADPH) oxidase - derived reactive oxygen species ( ROS) stimulate a Ca2+ influx into the cytoplasm that is required for root hair growth in Arabidopsis thaliana. We found that Ca2+, in turn, activated the RHD2 NADPH oxidase to produce ROS at the growing point in the root hair. Together, these components could establish a means of positive feedback regulation that maintains an active growth site in expanding root hair cells. Because the location and stability of growth sites predict the ultimate form of a plant cell, our findings demonstrate how a positive feedback mechanism involving RHD2, ROS, and Ca2+ can determine cell shape.