EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN INVASIVE TRANSITIONAL-CELL CARCINOMA OF THE URINARY-BLADDER - A MULTIVARIATE SURVIVAL ANALYSIS
EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN INVASIVE TRANSITIONAL-CELL CARCINOMA OF THE URINARY-BLADDER - A MULTIVARIATE SURVIVAL ANALYSIS
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DOI：
10.1093/ajcp/101.2.166
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发表时间：
1994-02-01
影响因子：
3.5
通讯作者：
NIEHANS, GA
中科院分区：
文献类型：
--
作者：
NGUYEN, PL;SWANSON, PE;NIEHANS, GA
对85例浸润性膀胱移行细胞癌进行表皮生长因子受体（EGFR）免疫反应性检测。EGFR染色对患者生存的影响与肿瘤分期、组织学分级、c-er B B-2和增殖细胞核抗原的免疫反应性、流式细胞术测定的S期分数和DNA倍体、血型相关抗原的异常表达和患者血型进行比较。作者使用一种新的单克隆抗EGFR抗体在福尔马林固定的组织中反应，发现EGFR表达与高肿瘤分期之间以及EGFR表达与患者预后不良之间存在显著相关性。然而，EGFR表达作为预后的预测因子并不独立于分期。注意到患者血型和患者生存率之间存在有趣的关联。在对分期数据进行调整后，其他指标不能预测患者结局。
Epidermal growth factor receptor (EGFR) immunoreactivity was evaluated in 85 cases of invasive transitional cell carcinoma of the bladder. The impact of EGFR staining on patient survival was compared with tumor stage, histologic grade, immunoreactivity for c-erb B-2 and proliferating cell nuclear antigen, flow cytometrically determined S-phase fraction and DNA ploidy, abnormal expression of blood-group-related antigens, and patient blood type. Using a new monoclonal anti-EGFR antibody reactive in formalin-fixed tissue, the authors found a significant correlation between EGFR expression and high tumor stage, and between EGFR expression and poor patient outcome. However, EGFR expression as a predictor of prognosis was not independent of stage. An intriguing association between patient blood type and patient survival was noted. Other indices did not predict patient outcome after data were adjusted for stage.