Intestinal Lymphatic Dysfunction in Kidney Disease.
Intestinal Lymphatic Dysfunction in Kidney Disease.
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DOI：
10.1161/circresaha.122.321671
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发表时间：
2023-04-28
影响因子：
20.1
通讯作者：
Kon, Valentina
中科院分区：
文献类型：
--
作者：
Zhong, Jianyong;Kirabo, Annet;Yang, Hai-Chun;Fogo, Agnes B.;Shelton, Elaine L.;Kon, Valentina
肾脏疾病与肾脏以外的许多器官的不良后果有关，包括心脏、肺、大脑和肠道。肾肠相互作用涉及肠上皮损伤、菌群失调和尿毒症毒素的产生。最近的研究表明，肾损伤会扩张肠道淋巴管，增加淋巴流量，并改变肠系膜淋巴的成分。肠道淋巴管与血管一样，是运输肠道产生的潜在有害物质的途径。淋巴管的结构和作用特别适合吸收和运输大分子，其功能将其与血管区分开来，使它们能够在各种生理和病理过程中发挥独特的作用。在这里，我们重点关注肾脏疾病导致肠道淋巴管发生有害变化的机制，并考虑有害器官串扰恶性循环的新范例。这一概念涉及肾损伤引起的肠道淋巴管调节，促进有害因子的产生和分布，进而导致远处器官系统的疾病进展。
Kidney disease is associated with adverse consequences in many organs beyond the kidney, including the heart, lungs, brain, and intestines. The kidney-intestinal cross talk involves intestinal epithelial damage, dysbiosis, and generation of uremic toxins. Recent studies reveal that kidney injury expands the intestinal lymphatics, increases lymphatic flow, and alters the composition of mesenteric lymph. The intestinal lymphatics, like blood vessels, are a route for transporting potentially harmful substances generated by the intestines. The lymphatic architecture and actions are uniquely suited to take up and transport large macromolecules, functions that differentiate them from blood vessels, allowing them to play a distinct role in a variety of physiological and pathological processes. Here, we focus on the mechanisms by which kidney diseases result in deleterious changes in intestinal lymphatics and consider a novel paradigm of a vicious cycle of detrimental organ cross talk. This concept involves kidney injury–induced modulation of intestinal lymphatics that promotes production and distribution of harmful factors, which in turn contributes to disease progression in distant organ systems.
影响因子：
8
作者：
Zhong, Jianyong;Yang, Hai -Chun;Shelton, Elaine L.;Matsusaka, Taiji;Clark, Amanda J.;Yermalitsky, Valery;Mashhadi, Zahra;May-Zhang, Linda S.;Linton, MacRae F.;Fogo, Agnes B.;Kirabo, Annet;Davies, Sean S.;Kon, Valentina
通讯作者：
Kon, Valentina