ALTERATION OF VOLTAGE-DEPENDENCE OF SHAKER POTASSIUM CHANNEL BY MUTATIONS IN THE S4-SEQUENCE
ALTERATION OF VOLTAGE-DEPENDENCE OF SHAKER POTASSIUM CHANNEL BY MUTATIONS IN THE S4-SEQUENCE
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DOI：
10.1038/349305a0
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发表时间：
1991-01-24
期刊：
影响因子：
64.8
通讯作者：
JAN, LY
中科院分区：
文献类型：
--
作者：
PAPAZIAN, DM;TIMPE, LC;JAN, LY
电压依赖性钾、钠和钙离子通道可能具有共同的激活机制，其中保守的S4序列作为主要的电压传感器。 Shaker钾通道S4序列的定点突变和电生理分析表明，电压依赖性激活涉及S4序列，但不仅仅是由于静电相互作用。
Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.