Are filarial nematode Wolbachia obligate mutualist symbionts?
Are filarial nematode Wolbachia obligate mutualist symbionts?
复制标题
DOI：
10.1016/j.tree.2004.01.002
复制
发表时间：
2004-04-01
影响因子：
16.8
通讯作者：
Blaxter, M
中科院分区：
文献类型：
--
作者：
Fenn, K;Blaxter, M
丝状线虫的胞内共生细菌为使用抗菌药物控制疾病提供了新的思路。为了有效的、长期的控制，这需要这些细菌对它们的线虫宿主是必不可少的。最近的两项研究提供了相互矛盾的证据：大多数丝状线虫和它们的共生体之间长期密切的共同进化与许多物种自然失去它们形成鲜明对比。试图将共生体转移到未感染的宿主上，发现细菌没有茁壮成长，这表明它们适应了一个宿主。
The intracellular symbiotic bacteria of filarial nematodes have inspired new ideas for the control of disease using antibacterial drugs. For effective, long-term control, this requires that the bacteria are essential to their nematode hosts. Two recent studies offer conflicting evidence: long, close coevolution between most filarial nematodes and their symbionts contrasts with many species having naturally lost them. An attempt to transfer symbionts to an uninfected host found that the bacteria did not thrive, suggesting they are adapted to one host.