PERSISTENCE OF MATERNAL ANTIBODY IN INFANTS BEYOND 12 MONTHS - MECHANISM OF MEASLES-VACCINE FAILURE
PERSISTENCE OF MATERNAL ANTIBODY IN INFANTS BEYOND 12 MONTHS - MECHANISM OF MEASLES-VACCINE FAILURE
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DOI：
10.1016/s0022-3476(77)81021-4
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发表时间：
1977-01-01
影响因子：
5.1
通讯作者：
KRUGMAN, S
中科院分区：
文献类型：
--
作者：
ALBRECHT, P;ENNIS, FA;KRUGMAN, S
对34例12个月龄麻疹疫苗免疫儿童进行了血清学研究。使用敏感的病毒中和试验，发现许多儿童已存在麻疹病毒母源抗体。既往抗体效价高的儿童血清转换失败。既有抗体滴度较低的儿童血清转换，但所产生的抗体滴度显著低于没有预先存在抗体滴度的儿童。这项研究的结果证明了12个月大儿童麻疹疫苗失败的可能机制，并支持公共卫生服务免疫实践咨询委员会将麻疹疫苗接种推迟到15个月的建议。年纪大了。
A serologic study was made in 34 children immunized against measles at the age of 12 mo. Using a sensitive virus neutralization test, it was found that many of the children had pre-existing maternal antibody to measles virus. Children with high pre-existing antibody titers failed to seroconvert. Children with lower pre-existing antibody titers seroconverted, but the resulting antibody titer was significantly lower than in children without pre-existing antibody titer. The results of this study demonstrate a probable mechanism for measles vaccine failure in 12-month-old children and support the recommendation of the Public Health Service Advisory Committee on Immunization Practices to postpone measles vaccine to 15 mo. of age.