Polypeptoids: A perfect match for molecular definition and macromolecular engineering?
Polypeptoids: A perfect match for molecular definition and macromolecular engineering?
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DOI：
10.1002/pola.26687
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发表时间：
2013-07-01
影响因子：
--
通讯作者：
Grossmann, Arlett
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文献类型：
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作者：
Luxenhofer, Robert;Fetsch, Corinna;Grossmann, Arlett
聚合物的精密合成一直是近年来的热门话题。虽然众所周知，对于具有 CC 主链的聚合物来说，这个问题很难解决，但 Merrifield 在几十年前就发现了一种解决多肽问题的方法。使用类似的方法，N-取代的多肽，即所谓的类多肽，已经被合成并研究了大约 20 年。相比之下，N-取代的N-羧酸酐的活性开环聚合（ROP）是最早发现的活性聚合之一。最近，新合成方法的激增导致了环状或线性多嵌段共聚肽的有效合成。因此，可以通过固相合成来合成类肽，以产生复杂且精确定义的寡聚物和小聚合物，或者通过适当的N-取代的N-羧酸酐(NNCA)的ROP来合成，以得到线性、环状或星状聚合物。加上出色的生物相容性，该聚合物系列作为生物材料可能拥有光明的前景。 (c) 2013 年 Wiley periodicals, Inc. J. Polym。科学，A 部分：聚合物。化学。 2013, 51, 2731-2752
Precision synthesis of polymers has been a hot topic in recent years. While this is notoriously difficult to address for polymers with a CC backbone, Merrifield has discovered a way many decades ago for polypeptides. Using a similar approach, N-substituted polypeptides, so-called polypeptoids have been synthesized and studied for about 20 years. In contrast, the living ring-opening polymerization (ROP) of N-substituted N-carboxyanhydrides was among the first living polymerizations to be discovered. More recently, a surge in new synthetic approaches led to the efficient synthesis of cyclic or linear multiblock copolypeptoids. Thus, polypeptoids can be synthesized either by solid phase synthesis to yield complex and exactly defined oligo- and small polymers or by ROP of appropriately N-substituted N-carboxyanhydrides (NNCA) to give linear, cyclic, or star-like polymers. Together with an excellent biocompatibility, this polymer family may have a bright future ahead as biomaterials. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 2731-2752