Vascular microinvasion from hepatocellular carcinoma: CT findings and pathologic correlation for the best therapeutic strategies
Vascular microinvasion from hepatocellular carcinoma: CT findings and pathologic correlation for the best therapeutic strategies
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DOI：
10.1007/s12032-017-0949-7
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发表时间：
2017-05-01
期刊：
影响因子：
3.4
通讯作者：
Cappabianca, Salvatore
中科院分区：
文献类型：
--
作者：
Reginelli, Alfonso;Vanzulli, Angelo;Cappabianca, Salvatore
肝癌的复发降低了手术患者的生存率，而肿瘤复发最相关的危险因素之一是微血管侵袭（mVI）。术前检查中mVI的识别可以改善手术计划和技术，从而降低肿瘤复发的风险。在我们的研究中，我们修改了101例被诊断为孤立性HCC并接受手术治疗的患者的肝脏CT检查，并对mVI标本进行了病理分析，以发现可以可靠预测mVI的CT征象。在CT检查中，评估肿瘤的边缘，包膜，大小，对比增强，晕征和Thad。从我们的统计分析中，我们发现肿瘤边缘的不规则性和瘤周包膜的缺陷是预测HCC中mVI最重要的特征。每一份外科候选患者的CT检查报告都应包括mVI概率的建议，以便定制手术方案，降低肿瘤复发风险，提高生存率。
Recurrence of HCC reduces survival rates in patients treated with surgery, and one of the most relevant risk factors for tumour recurrence is microvascular invasion (mVI). The identification of mVI on preoperative examinations could improve surgical planning's and techniques so as to reduce the risk of tumour recurrence. During our study, we have revised 101 CT examinations of the liver performed on patients diagnosed with solitary HCC who had surgical treatment and pathological analysis of the specimens for mVI in order to detect CT signs which could be reliable in mVI prediction. On CT examinations, the tumours were evaluated for margins, capsule, size, contrast enhancement, halo sign and Thad. From our statistical analysis, we found out that irregularity in tumour margins and defects in peritumoural capsule are the most significant characteristics predicting mVI in HCC. Every report on CT examinations performed on surgical candidate patients should include suggestions about mVI probability in order to tailor procedures, reduce tumour recurrence risk and improve survival rates.