Self-reported food intolerance in chronic inflammatory bowel disease
Self-reported food intolerance in chronic inflammatory bowel disease
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DOI：
10.3109/00365529709025101
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发表时间：
1997-06-01
影响因子：
1.9
通讯作者：
Ladefoged, K
中科院分区：
文献类型：
--
作者：
Ballegaard, M;Bjergstrom, A;Ladefoged, K
背景：虽然有建议，但从未有令人信服的文献证明食物敏感性在慢性炎症性肠病中具有重要的致病作用。然而，许多患者可能将其胃肠道症状与摄入的特定食物联系起来，并可能相应地限制其饮食。方法：对1993年在丹麦科格市罗斯基勒县医院内科门诊就诊的所有慢性炎症性肠病患者进行问卷调查。研究人员询问患者是否对某种特定的食物有问题，如果有，请描述由此产生的症状。对照组为70名健康人。结果：189例患者中，132例（70%）缓解。130人完成问卷，男性52人，女性78人，年龄13-89岁（中位数43岁）。53人（41%）患有克罗恩病（CD）， 69人（53%）患有溃疡性结肠炎（UC）， 8人（6%）患有未分类结肠炎。手术41例（CD 31例，UC 10例）；51例（CD 19例，UC 32例）有疾病活动。65%的患者和14%的对照组报告对一种或多种食物不耐受（P < 0.0001）。这种不耐症涵盖了很多种食品。患者中最常见的症状是腹泻、腹痛和呕吐，对照组中最常见的症状是反流。食物不耐受在乳糜泻（66%）和UC（64%）中同样常见，且与既往手术、疾病活动或疾病部位无关。结论：大多数慢性炎症性肠不耐受患者对不同的食物不耐受，可相应限制饮食。食物不耐受的频率和模式在乳糜泻和UC患者之间没有差异。这种食物不耐受可能不是特异性的，而不是致病的重要性。
Background: Although suggested, it has never been convincingly documented that food sensitivity is of pathogenetic importance in chronic inflammatory bowel disease. However, many patients may relate their gastrointestinal symptoms to specific food items ingested and may restrict their diet accordingly. Methods: A questionnaire was sent to all patients with chronic inflammatory bowel disease who attended the outpatient clinic, Medical Dept., Roskilde County Hospital in Koge, Denmark, in the year 1993. The patients were asked whether they had problems with any particular food item and, if so, to describe the symptoms experienced from it. A control group of 70 healthy persons were included. Results: Among 189 patients, 132 (70%) responded. One hundred and thirty had completed the questionnaire, 52 males and 78 females aged 13-89 years (median, 43 years). Fifty-three (41%) had Crohn's disease (CD), 69 (53%) ulcerative colitis (UC), and 8 (6%) unclassified colitis. Forty-one patients (31 CD, 10 UC) were operated on; 51 (19 CD, 32 UC) had disease activity. Sixty-five per cent of the patients and 14% of the controls reported being intolerant to one or more food items (P < 0.0001). The intolerance covered a wide range of food products. The commonest symptoms among patients were diarrhoea, abdominal pain, and meteorism and among controls, regurgitation. Food intolerance was equally common in CD (66%) and UC (64%) and was not related to previous operation, disease activity or disease location. Conclusion: Most patients with chronic inflammatory bowel intolerance disease feel intolerant to different food items and may restrict their diet accordingly. The frequency and pattern of food intolerance did not differ between patients with CD and UC. The food intolerance was probably unspecific rather than of pathogenetic importance.