Resistance, tolerance and environmental transmission dynamics determine host extinction risk in a load-dependent amphibian disease.
Resistance, tolerance and environmental transmission dynamics determine host extinction risk in a load-dependent amphibian disease.
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抵抗力、耐受力和环境传播动态决定了负载依赖性两栖动物疾病的宿主灭绝风险。
DOI：
10.1111/ele.12814
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发表时间：
2017
期刊：
影响因子：
8.8
通讯作者：
C. Briggs
中科院分区：
文献类型：
--
作者：
M. Wilber;R. Knapp;Mary H. Toothman;C. Briggs
虽然疾病引起的灭绝通常被认为是罕见的，但最近出现的一些具有负荷依赖病理的传染病导致了野生动物种群的灭绝。传播是影响疾病引起的灭绝的一个关键因素，但与负荷依赖的宿主抗性和耐受性相比，传播的相对重要性目前尚不清楚。通过对一种被真菌病原体Batrachochytrium dendroatidis （Bd）灭绝的两栖动物进行模型和实验的结合，我们发现，虽然环境中Bd储存库的传播增加了Bd入侵两栖动物种群的能力和该种群的灭绝风险，但Bd诱导的灭绝动力学对宿主的抗性和耐受性比对Bd传播更为敏感。我们证明，这是负载依赖性病原体的一般结果，其中非线性抗性和耐受性功能可以相互作用，使得这些功能的微小变化导致灭绝动力学的剧烈变化。
While disease-induced extinction is generally considered rare, a number of recently emerging infectious diseases with load-dependent pathology have led to extinction in wildlife populations. Transmission is a critical factor affecting disease-induced extinction, but the relative importance of transmission compared to load-dependent host resistance and tolerance is currently unknown. Using a combination of models and experiments on an amphibian species suffering extirpations from the fungal pathogen Batrachochytrium dendrobatidis (Bd), we show that while transmission from an environmental Bd reservoir increased the ability of Bd to invade an amphibian population and the extinction risk of that population, Bd-induced extinction dynamics were far more sensitive to host resistance and tolerance than to Bd transmission. We demonstrate that this is a general result for load-dependent pathogens, where non-linear resistance and tolerance functions can interact such that small changes in these functions lead to drastic changes in extinction dynamics.
影响因子：
3.4
作者：
Lee, Young-Seon;Liu, Ona Z.;Sobie, Eric A.
通讯作者：
Sobie, Eric A.
影响因子：
3.4
作者：
Sobie, Eric A.
通讯作者：
Sobie, Eric A.