A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
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小鼠 10 号染色体的遗传连锁图：使用单个种间回交定位 18 个分子标记。
DOI：
10.1093/genetics/125.4.855
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发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
Jenkins,NA
中科院分区：
文献类型：
--
作者：
Justice,MJ;Siracusa,LD;Gilbert,DJ;Heisterkamp,N;Groffen,J;Chada,K;Silan,CM;Copeland,NG;Jenkins,NA
采用鼠种间回交分析，绘制了鼠10号染色体的分子遗传连锁图谱。确定Act-2、Ahi-1、Bcr、Braf、Cdc-2a、Col6a-1、Col6a-2、Cos-1、Esr、Fyn、Gli、Ifg、Igf-1、Myb、Pah、pgcha、Ros-1和S100b基因座的图谱位置。这些基因座延伸了染色体遗传长度的80%以上，首次提供了进入10号染色体许多区域的分子途径。本研究的基因定位扩展了小鼠第10号染色体与人类第6、10、12和21号染色体之间已知的同源区域，并揭示了小鼠第10号染色体与人类第22号染色体之间的一个新的同源片段。有几个基因座可能靠近或对应于已知的突变。在小鼠10号染色体的中心区域，观察到繁殖小家鼠衍生等位基因的优先传播。
Interspecific mouse backcross analysis was used to generate a molecular genetic linkage map of mouse chromosome 10. The map locations of the Act-2, Ahi-1, Bcr, Braf, Cdc-2a, Col6a-1, Col6a-2, Cos-1, Esr, Fyn, Gli, Ifg, Igf-1, Myb, Pah, pgcha, Ros-1 and S100b loci were determined. These loci extend over 80% of the genetic length of the chromosome, providing molecular access to many regions of chromosome 10 for the first time. The locations of the genes mapped in this study extend the known regions of synteny between mouse chromosome 10 and human chromosomes 6, 10, 12 and 21, and reveal a novel homology segment between mouse chromosome 10 and human chromosome 22. Several loci may lie close to, or correspond to, known mutations. Preferential transmission of Mus spretus-derived alleles was observed for loci mapping to the central region of mouse chromosome 10.