Formation of water-in-oil (W/O) nano-emulsions in a water/mixed non-ionic surfactant/oil systems prepared by a low-energy emulsification method
Formation of water-in-oil (W/O) nano-emulsions in a water/mixed non-ionic surfactant/oil systems prepared by a low-energy emulsification method
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DOI：
10.1016/j.colsurfa.2004.03.039
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发表时间：
2004-12
期刊：
影响因子：
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通讯作者：
N. Uson;M. J. García;C. Solans
中科院分区：
文献类型：
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作者：
N. Uson;M. J. García;C. Solans
首次报道了用低能乳化法制备W/O型纳米乳液。通过将肉豆蔻酸异丙酯缓慢添加到表面活性剂/水混合物中，在Cremophor EL：Cremophor WO 7表面活性剂/肉豆蔻酸异丙酯混合体系中以Cremophor EL：Cremophor WO 7比率在1：2和1：9之间形成纳米乳液。相行为研究表明，产生W/O纳米乳液的组合物属于多相区域，其中一个相是层状液晶相。当Cremophor EL：Cremophor WO 7比例从1：8增加到1：2时，在85%的固定油浓度和70/30的混合表面活性剂/水比例下的纳米乳液的液滴尺寸在60至160 nm的范围内。这些纳米乳液显示出高的动力学稳定性。在具有85%油浓度的水/Cremophor EL：Cremophor WO 7 1：8/肉豆蔻酸异丙酯体系的纳米乳液中，在5个月期间没有观察到相分离，尽管液滴尺寸随时间而增加。
W/O nano-emulsion formation by a low-energy emulsification method is described for the first time. The nano-emulsions have been formed in water/mixed Cremophor EL:Cremophor WO7 surfactant/isopropyl myristate systems at Cremophor EL:Cremophor WO7 ratios between 1:2 and 1:9, by slow addition of isopropyl myristate to surfactant/water mixtures. Phase behaviour studies have showed that the compositions giving rise to W/O nano-emulsions belong to multiphase regions, one of the phases being a lamellar liquid crystalline phase. The droplet size of the nano-emulsions at a fixed oil concentration of 85% and mixed surfactants/water ratio of 70/30 ranged from 60 to 160nm as Cremophor EL:Cremophor WO7 ratio increased from 1:8 to 1:2. These nano-emulsions showed high kinetic stability. No phase separation was observed during 5 months in nano-emulsions of the water/Cremophor EL:Cremophor WO7 1:8/isopropyl myristate system with 85% oil concentration, although droplet size experienced an increase with time.