COLORECTAL-CARCINOMA ANTIGENS DETECTED BY HYBRIDOMA ANTIBODIES
COLORECTAL-CARCINOMA ANTIGENS DETECTED BY HYBRIDOMA ANTIBODIES
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DOI：
10.1007/bf01542654
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
FUHRER, P
中科院分区：
文献类型：
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作者：
KOPROWSKI, H;STEPLEWSKI, Z;FUHRER, P
产生分泌结直肠癌特异性抗体的杂交瘤细胞，并用于研究这些[人类]肿瘤细胞的抗原结构。详细研究了19种抗体，其中15种是结直肠癌特异性抗体。仅发现了2种与癌胚抗原（CEA）反应的抗体，并确定了5种与细胞表面不同表位反应的其他抗体。用杂交瘤抗体发现了几种具有不同分子特征的抗原。六种杂交瘤抗体介导抗体依赖性细胞介导的细胞毒性（ADCC）。
Hybridoma cells which secrete colorectal carcinoma-specific antibodies were produced and used to study the antigenic structure of these [human] tumor cells. Nineteen antibodies were studied in detail; 15 of these were colorectal carcinoma specific. Only 2 antibodies reactive with carcinoembryogenic antigen (CEA) were discovered and 5 other antibodies that react with distinct epitopes on the cell surface were defined. Several antigens with distinct molecular characteristics were found with hybridoma antibodies. Six hybridoma antibodies mediated antibody-dependent cell-mediated cytotoxicity (ADCC).