CYSTEAMINE INDUCES DUODENAL-ULCER IN THE MOUSE
CYSTEAMINE INDUCES DUODENAL-ULCER IN THE MOUSE
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DOI：
10.1159/000199303
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发表时间：
1986-01-01
期刊：
影响因子：
3.2
通讯作者：
SZABO, S
中科院分区：
文献类型：
--
作者：
CAHILL, MC;GALLAGHER, GT;SZABO, S
一种新的十二指肠溃疡病模型已经在小鼠中建立。溃疡是在口服或皮下给予半胱胺后产生的，半胱胺已显示在大鼠中引起十二指肠溃疡。半胱胺经口给药后以时间和剂量依赖性方式诱导十二指肠溃疡。新的小鼠模型与大鼠模型和人类溃疡病有许多相似之处。半胱胺引起胃酸和胃蛋白酶活性的显着增加。多巴胺受体激动剂麦角腈或组胺H2受体拮抗剂西咪替丁均能保护小鼠免受半胱胺诱导的十二指肠溃疡。这种小鼠十二指肠溃疡疾病的新模型可能代表了一种筛选新的抗溃疡药物的简单而廉价的方法。
A new model of doudenal ulcer disease has been developed in the mouse. The ulcers were produced after either oral or subcutaneous administration of cysteamine which has been shown to cause duodenal ulcer in the rat. Cystemine induced duodenal ulcers in a time- and dose-dependent manner after oral administration. The new mouse model shares many similarities with both the rat model and human ulcer disease. Cysteamine caused a significant increase in gastric acidity and pepsin activity. The mouse can be protected against the cysteamine-induced duodenal ulcer by either the dopamine agonist lergotrile or histamine H2 receptor antagonist cimetidine. This new model of duodenal ulcer disease in the mouse may represent a simple and inexpensive way to screen for new antiulcerogenic drugs.