A global scientific strategy to cure hepatitis B
A global scientific strategy to cure hepatitis B
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DOI：
10.1016/s2468-1253(19)30119-0
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发表时间：
2019-07-01
影响因子：
35.7
通讯作者：
Zoulim, Fabien
中科院分区：
文献类型：
--
作者：
Revill, Peter A.;Chisari, Francis V.;Zoulim, Fabien
慢性B型肝炎病毒（HBV）感染是一个全球性的公共卫生挑战，其规模与结核病、艾滋病毒和疟疾相当。国际消除乙肝联盟（ICE-HBV）是一个致力于加速发现慢性B型肝炎治愈方法的专家联盟。经过与来自地球仪的50多名科学家以及包括HBV感染者在内的主要利益相关者的广泛磋商，我们已经确定了我们现有知识的差距以及实现HBV治愈所需的新策略和工具。我们认为，研究必须集中在干预策略的发现，将永久减少生产性感染细胞的数量或永久沉默的共价闭合环状DNA在这些细胞中，并将刺激HBV特异性宿主免疫反应，模仿HBV感染的自发解决。此外，还迫切需要建立标准化HBV试剂和方案库，供全世界所有HBV研究人员使用。本立场文件中概述的HBV治疗研究议程将为消除全球HBV感染的目标做出显着贡献。
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.