Non-Coding RNAs in Endometrial Physiopathology.
Non-Coding RNAs in Endometrial Physiopathology.
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DOI:
10.3390/ijms19072120
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发表时间:
2018-07-20
影响因子:
5.6
通讯作者:
Pietro CD
中科院分区:
文献类型:
--
作者:
Ferlita A;Battaglia R;Andronico F;Caruso S;Cianci A;Purrello M;Pietro CD
The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.
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