Non-Coding RNAs in Endometrial Physiopathology.

Non-Coding RNAs in Endometrial Physiopathology.
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DOI:
10.3390/ijms19072120
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发表时间:
2018-07-20
影响因子:
5.6
通讯作者:
Pietro CD
Pietro CD
中科院分区:
生物学2区
文献类型:
--
作者:
Ferlita A;Battaglia R;Andronico F;Caruso S;Cianci A;Purrello M;Pietro CD

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人类基因组计划发现,大约80%的DNA被转录成RNA分子。只有2%的人类基因组被翻译成蛋白质,其余的大部分产生称为非编码RNA的分子,这是一种参与基因调控不同步骤的异质性RNA。根据它们的长度,它们被分为小的非编码RNA和长的非编码RNA,或者根据它们的功能,分为管家非编码RNA和调节非编码RNA。它们的参与已被广泛证明在所有细胞过程中,以及它们在人类病理学中的失调。本文就非编码RNA在子宫内膜生理学中的作用及其与胚胎着床的关系进行综述。此外,我们还探讨了它们在子宫内膜病变中的作用,如子宫内膜癌、子宫内膜异位症和慢性子宫内膜炎。
The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.
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