Up-regulated Golgi phosphoprotein 2 (GOLPH2) expression in lung adenocarcinoma tissue
Up-regulated Golgi phosphoprotein 2 (GOLPH2) expression in lung adenocarcinoma tissue
复制标题
肺腺癌组织中高尔基体磷蛋白 2 (GOLPH2) 表达上调
DOI：
10.1016/j.clinbiochem.2010.05.010
复制
发表时间：
2010-08-01
影响因子：
2.8
通讯作者：
Peng, Tao
中科院分区：
文献类型：
--
作者：
Zhang, Fangfang;Gu, Yanli;Peng, Tao
目的：本研究的目的是评估高尔基体磷蛋白2（GOLPH 2）在肺癌中的表达。设计和方法：GOLPH 2的表达进行了分析，从178例肺癌肿瘤组织标本，采用免疫组化。结果：133例肺癌患者血清GOLPH 2（sGOLPH 2）阳性率为100%，其中83.6%为胞浆弥漫性阳性。然而，对于鳞状细胞癌样品，仅16.3%显示强染色强度。GOLPH 2在ADC中的表达显著高于其他类型肺癌（P
Objectives: The aim of the study was to evaluate Golgi Phosphoprotein 2 (GOLPH2) expression in lung cancer.Design and methods: GOLPH2 expression was analyzed from 178 lung cancer tumor tissue samples using immunohistochemistry. Levels of 133 lung cancer patients' serum GOLPH2 (sGOLPH2) were also quantitatively compared with 70 healthy individuals by a sandwich enzyme-linked immunosorbent assay (ELISA).Results: All adenocarcinoma (ADC) tissue samples (100%) displayed strong staining, 83.6% of which displayed cytoplasmic diffused staining. However, for squamous cell carcinoma samples, only 16.3% displayed strong staining intensity. Statistically, GOLPH2 expression in tissues of ADC was significantly higher than in other types of lung cancer (P