A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them.
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them.
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DOI：
10.1083/jcb.200404129
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发表时间：
2004-10-25
期刊：
影响因子：
--
通讯作者：
Springer TA
中科院分区：
文献类型：
--
作者：
Carman CV;Springer TA
白细胞迁移通过内皮的基本途径和机制仍不清楚。我们提供了跨细胞（即，通过单独的内皮细胞）在体外的渗出，并证明了几乎所有的细胞帕拉和跨细胞渗出都发生在新的“杯状”跨迁移结构的背景下。这种内皮结构是由高度细胞间粘附分子-1-和血管细胞粘附分子-1-丰富的垂直微绒毛样的预测，周围的白细胞迁移和驱动重新分配的整合素成线性轨道定向平行于渗出的方向。投射的中断与迁移的抑制高度相关。这些发现表明了一种新的机制，即“transmigrationcup”，通过这种机制，内皮细胞为白细胞外渗提供了方向性指导。
The basic route and mechanisms for leukocyte migration across the endothelium remain poorly defined. We provide definitive evidence for transcellular (i.e., through individual endothelial cells) diapedesis in vitro and demonstrate that virtually all, both para- and transcellular, diapedesis occurs in the context of a novel “cuplike” transmigratory structure. This endothelial structure was comprised of highly intercellular adhesion molecule-1– and vascular cell adhesion molecule-1–enriched vertical microvilli-like projections that surrounded transmigrating leukocytes and drove redistribution of their integrins into linear tracks oriented parallel to the direction of diapedesis. Disruption of projections was highly correlated with inhibition of transmigration. These findings suggest a novel mechanism, the “transmigratory cup”, by which the endothelium provides directional guidance to leukocytes for extravasation.
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