Regulation of blood pressure by D5 dopamine receptors.
Regulation of blood pressure by D5 dopamine receptors.
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DOI：
10.2174/187152507781058708
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发表时间：
2007-06
影响因子：
--
通讯作者：
C. Zeng;Zhiwei Yang;L. Asico;P. Jose
中科院分区：
文献类型：
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作者：
C. Zeng;Zhiwei Yang;L. Asico;P. Jose
多巴胺受体已在许多器官和组织中被发现，包括中枢和周围神经系统、各种血管床、心脏、胃肠道和肾脏。多巴胺受体根据其结构和药理学分为 D1 和 D2 样亚型；在中等钠平衡条件下，超过 50% 的肾脏钠排泄是由 D1 样受体调节的。大多数关于多巴胺作用的知识都集中在 D1 多巴胺受体上。 D5 多巴胺受体也属于 D1 样受体亚家族。 D5 受体的破坏会导致高血压。然而，与D1受体不同，D5受体缺失小鼠的高血压是由交感神经系统活性增加引起的，这显然是由于中枢神经系统中催产素、V1加压素和非NMDA受体的激活所致。在本文中，我们回顾了D5受体对中枢和周围神经系统的生理作用，并讨论了当D5受体功能受到干扰时高血压发生的可能机制。
Dopamine receptors have been identified in a number of organs and tissues, which include the central and peripheral nervous systems, various vascular beds, the heart, the gastrointestinal tract, and the kidney. Dopamine receptors are classified into D1- and D2- like subtypes based on their structure and pharmacology; during conditions of moderate sodium balance, more than 50% of renal sodium excretion is regulated by D1-like receptors. Most of the knowledge on the actions of dopamine has been focused on the D1 dopamine receptor. The D5 dopamine receptor also belongs to the D1- like receptor subfamily. Disruption of the D5 receptor results in hypertension. However, unlike the D1 receptor, the hypertension in D5 receptor null mice is caused by the increased activity of the sympathetic nervous system, apparently due to activation of oxytocin, V1 vasopressin, and non-NMDA receptors in the central nervous system. In this paper, we review the physiological action of D5 receptor on the central and peripheral nervous systems, and discuss the possible mechanisms by which hypertension develops when the D5 receptor function is perturbed.