The effect of hyperthyroidism on opiate receptor binding and pain sensitivity.
The effect of hyperthyroidism on opiate receptor binding and pain sensitivity.
复制标题
甲状腺功能亢进症对阿片受体结合和疼痛敏感性的影响。
DOI：
10.1016/0024-3205(90)90160-s
复制
发表时间：
1990
期刊：
影响因子：
6.1
通讯作者：
Friedhoff,AJ
中科院分区：
文献类型：
--
作者：
Edmondson,EA;Bonnet,KA;Friedhoff,AJ
本研究旨在确定甲状腺激素对阿片受体配体结合和疼痛敏感性的影响。对Swiss-Webster小鼠的脑匀浆进行特异性阿片受体结合。在甲状腺素喂养的受试者（甲状腺功能亢进）中，3 H-纳洛酮结合显著增加。Scatchard分析显示，甲状腺功能亢进小鼠中阿片受体的数量增加（甲状腺功能亢进样品的Bmax = 0.238 nM，对照组为0.174 nM）。结合亲和力不受影响（甲状腺功能亢进症的Kd = 1.54 nM，对照样品的Kd = 1.58 nM）。当小鼠经受热板刺激时，注意到甲状腺功能亢进小鼠更敏感，如通过疼痛厌恶反应lavage所判断的，其是对照动物的一半。吗啡给药后，甲亢动物表现出较短的镇痛持续时间。这些结果表明，甲状腺素增加阿片受体的数量和天然的疼痛敏感性，但减少吗啡镇痛的持续时间。
This study was conducted to determine the effect of thyroid hormone on opiate receptor ligand-binding and pain sensitivity. Specific opiate receptor-binding was performed on brain homogenates of Swiss-Webster mice. There was a significant increase in3H-naloxone-binding in thyroxine-fed subjects (hyperthyroid). Scatchard analysis revealed that the number of opiate receptors was increased in hyperthyroid mice (Bmax = 0.238 nM for hyperthyroid samples vs. 0.174 nM for controls). Binding affinity was unaffected (Kd = 1.54 nM for hyperthyroid and 1.58 nM for control samples). When mice were subjected to hotplate stimulation, the hyperthyroid mice were noted to be more sensitive as judged by pain aversion response latencies which were half that of control animals. After morphine administration, the hyperthyroid animals demonstrated a shorter duration of analgesia. These findings demonstrate that thyroxine increases opiate receptor number and native pain sensitivity but decreases the duration of analgesia from morphine.