Ratiometric fluorescent probes for ClO- and in vivo applications
Ratiometric fluorescent probes for ClO- and in vivo applications
复制标题
用于 ClO 和体内应用的比率荧光探针
DOI：
10.1016/j.dyepig.2016.02.024
复制
发表时间：
2016-07-01
影响因子：
4.5
通讯作者：
Zhang, Yongbin
中科院分区：
文献类型：
--
作者：
Li, Jianfang;Li, Pengfei;Zhang, Yongbin
新合成的1,8-萘酰亚胺衍生物，1和2，在存在大量过量的其他竞争离子的情况下，发现它们的光学和荧光光谱行为发生了相关的变化。这些光谱变化在光谱的可见区域是足够显著的，因此，允许视觉检测。检测限低至10(-8)m .基于1,8-萘酰亚胺和碘化吲哚的分子内电荷转移（ICT）过程，1和2可作为比例传感器用于检测氯离子。此外，共聚焦激光显微研究证实探针1也可作为检测HepG2细胞中ClO-的成像探针。(C) 2016 Elsevier Ltd.版权所有。
Newly synthesized 1,8-naphthalimide derivatives, 1 and 2, are found to detect specifically ClO- in presence of large excess of other competing ions with associated changes in their optical and fluorescence spectral behavior. These spectral changes are significant enough in the visible region of the spectrum and thus, allow the visual detection. The detection limit is low as 10(-8) M.1 and 2 could be used as ratiometric sensors for detection of ClO- based on the intramolecular charge transfer (ICT) process involving the donor 1,8-naphthalimide and the acceptor indolium iodide. Further, confocal laser microscopic studies confirmed that the probe 1 could also be used as imaging probe for detection of ClO- in HepG2 cells. (C) 2016 Elsevier Ltd. All rights reserved.