Modulating Accidental Fermi Resonance: What a Difference a Neutron Makes.
Modulating Accidental Fermi Resonance: What a Difference a Neutron Makes.
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DOI：
10.1021/jz2006447
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发表时间：
2011-06-27
期刊：
影响因子：
--
通讯作者：
Brewer SH
中科院分区：
文献类型：
--
作者：
Lipkin JS;Song R;Fenlon EE;Brewer SH
振动记者已经显示出作为蛋白质和核酸中局部环境的灵敏探测器的重大前景。两个潜在的振动探针，分别是氰酸苯酯和3-叠氮吡啶中的氰酸酯和叠氮基，由于意外的费米共振而受到阻碍。基波OCN或-N3非对称伸缩振动与接近共振的组合带之间的非简谐耦合，导致每个探头的吸收轮廓都非常宽和复杂。合成并研究了8个氰酸苯酯和6个3-叠氮吡啶同分异构体。同位素编辑有效地调制了偶然的费米共振--几个同位素异构体的吸收曲线大大简化，而其他同位素异构体的吸收轮廓仍然复杂。文中还讨论了观测剖面的来源。在振荡器的中间原子中添加一个中子，就可以将吸收曲线转换为一个吸收谱带，这是氰酸盐或叠氮化合物不对称伸缩振动的结果。
Vibrational reporters have shown significant promise as sensitive probes of local environments in proteins and nucleic acids. The utility of two potential vibrational probes, the cyanate and azide groups in phenyl cyanate and 3-azidopyridine, respectively, has been hindered by accidental Fermi resonance. Anharmonic coupling, between the fundamental –OCN or –N3 asymmetric stretch vibration with a near resonant combination band, results in an extremely broad and complex absorption profile for each of these probes. A total of eight phenyl cyanate and six 3-azidopyridine isotopomers were synthesized and studied. Isotopic editing effectively modulated the accidental Fermi resonance — the absorption profiles of several isotopomers were greatly simplified while others remained complex. The origins of the observed profiles are discussed. Addition of a single neutron to the middle atom of the oscillator converted the absorption profile to essentially a single band resulting from either the cyanate or azide asymmetric stretch vibration.
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DOI：
10.1039/c0cp02774j
发表时间：
2011-04-07
期刊：
Physical chemistry chemical physics : PCCP
影响因子：
--
作者：
Gai XS;Coutifaris BA;Brewer SH;Fenlon EE
通讯作者：
Fenlon EE
影响因子：
3.3
作者：
Hill, Sarah E.;Bandaria, Jigar N.;Cheatum, Christopher M.
通讯作者：
Cheatum, Christopher M.
影响因子：
3.3
作者：
Gai, Xin Sonia;Fenlon, Edward E.;Brewer, Scott H.
通讯作者：
Brewer, Scott H.
影响因子：
1.8
作者：
BRADLEY, DH;HANNA, MM
通讯作者：
HANNA, MM
DOI：
10.1073/pnas.0700804104
发表时间：
2007-09-04
影响因子：
11.1
作者：
Shim, Sang-Hee;Strasfeld, David B.;Zanni, Martin T.
通讯作者：
Zanni, Martin T.