Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload
Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload
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DOI：
10.1016/s0031-9384(00)00393-0
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发表时间：
2001-01-01
影响因子：
2.9
通讯作者：
Moran, TH
中科院分区：
文献类型：
--
作者：
Emond, M;Ladenheim, EE;Moran, TH
瘦素通过减少膳食量来影响食物摄入，这表明它可以调节餐内饱腹感信号的功效。为了评估瘦素是否会放大营养性胃前负荷的摄食抑制作用，我们比较了脑室内瘦素（3.5 μ g）、胃内Ensure（10分钟内10 ml）或其组合对流质饮食食物摄入和c-Fos激活的反应模式。单独使用瘦素并不影响Ensure摄入量，但显着增加了胃内前负荷对摄入量的抑制。在孤束核（NTS）内，单独的瘦素并不刺激c-Fos，但显着增加c-Fos阳性细胞的数量，在内侧和吻侧水平的胃内Ensure。在室旁核（PVN），瘦素和胃负荷刺激c-Fos表达，但组合导致显着更多的c-Fos阳性细胞。这些数据表明，瘦素调节由进食相关信号产生的摄食抑制，并提示这种调节发生在NTS和PVN水平。(C)2001 Elsevier Science Inc. All rights reserved.
Leptin affects food intake by reducing meal size, suggesting that it may modulate the efficacy of within-meal satiety signals. To assess whether leptin would amplify the feeding inhibitory actions of a nutrient gastric preload, we compared liquid diet food intake and patterns of c-Fos activation in response to intraventricular leptin (3.5 mug), intragastric Ensure (10 mi over 10 min), or their combination. Leptin alone did not affect Ensure intake but significantly increased the suppression of intake produced by the intragastric preload. Within the nucleus of the solitary tract (NTS), leptin alone did not stimulate c-Fos but significantly elevated the number of c-Fos positive cells in response to intragastric Ensure at medial and rostral levels. Within the paraventricular nucleus (PVN), both leptin and the gastric load stimulated c-Fos expression, but the combination resulted in significantly greater number of c-Fos positive cells. These data demonstrate that leptin modulates the feeding inhibition produced by meal-related signals and suggest that this modulation occurs at the levels of the NTS and PVN.;(C) 2001 Elsevier Science Inc. All rights reserved.