NF-κB activation in cerebrospinal fluid cells from patients with meningitis
NF-κB activation in cerebrospinal fluid cells from patients with meningitis
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DOI：
10.1179/016164102101200627
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发表时间：
2002-10-01
影响因子：
1.9
通讯作者：
Furukawa, S
中科院分区：
文献类型：
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作者：
Ichiyama, T;Isumi, H;Furukawa, S
我们研究了是否NF-κ B，一个因子，调节基因的表达，编码促炎细胞因子，在脑脊液（CSF）细胞中被激活，以研究脑膜炎患者的CSF细胞的促炎细胞因子的生产。Western blotting结果显示，细菌性脑膜炎患者脑脊液中NF-κ B的活化程度高于无菌性脑膜炎患者。NF-κ B在癌性脑膜炎中几乎没有激活。脑膜炎患者脑脊液细胞NF-κ B的活化与脑脊液中IL-6的浓度有相关性。我们的数据表明，CSF细胞通过NF-κ B活化产生促炎细胞因子在脑膜炎中，并且CSF细胞中NF-κ B活化的增加指示感染性脑膜炎而不是癌性脑膜炎。
We examined whether or not NF-kappaB, a factor that regulates expression of the genes that code for pro-inflammatory cytokines, is activated in cerebrospinal fluid (CSF) cells to investigate the production of pro-inflammatory cytokines by CSF cells in patients with meningitis. Western blotting demonstrated that NF-kappaB was more activated in CSF cells of patients with bacterial meningitis than in those of patients with aseptic meningitis. NF-kappaB was hardly activated in carcinomatous meningitis. The NF-kappaB activation in CSF cells of patients with meningitis tended to be correlated with the CSF interleukin-6 concentration. Our data suggested that CSF cells produce pro-inflammatory cytokines through NF-kappaB activation in meningitis, and that increased NF-kappaB activation in CSF cells indicate infectious meningitis rather than carcinomatous meningitis.