THE ARCHITECTURE OF RAT LYMPH-NODES .1. COMBINED LIGHT AND ELECTRON-MICROSCOPY OF LYMPH-NODE CELL-TYPES
THE ARCHITECTURE OF RAT LYMPH-NODES .1. COMBINED LIGHT AND ELECTRON-MICROSCOPY OF LYMPH-NODE CELL-TYPES
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DOI：
10.1007/bf00298513
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
VAALAND, JL
中科院分区：
文献类型：
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作者：
FOSSUM, S;VAALAND, JL
本文描述了正常成年大鼠、先天性无胸腺大鼠、无菌大鼠、受照射大鼠或新生大鼠的淋巴结中非淋巴细胞，采用的是光镜与电镜相结合的方法。这些细胞分为基质细胞和非基质细胞。后一类由多种形态各异且具有特征性分布模式的细胞类型组成。在无菌大鼠、无胸腺大鼠以及新生的有胸腺和无胸腺大鼠的淋巴结中存在副皮质区交错突细胞，这反驳了交错突细胞在免疫刺激或T细胞影响下由巨噬细胞分化而来的观点。通过照射排空淋巴细胞的滤泡后，滤泡树突状细胞能更清晰地被观察到，并且似乎是多核的。在常规饲养的有胸腺和无胸腺大鼠中可发现滤泡树突状细胞和易染体巨噬细胞，但在无菌大鼠中未发现。文中还讨论了这些以及其他类型的非淋巴细胞之间的相互关系。
Non-lymphoid cells in rat lymph nodes are described as seen by combined light microscopy and EM of normal adult, congenitally athymic, germ-free, irradiated, or newborn rats. The cells are divided into stromal and non-stromal. The latter category consists of a variety of morphologically distinct cell types with characteristic distribution patterns. The presence of paracortical interdigitating cells in lymph hodes of germ-free rats, athymic rats, and newborn euthymic and athymic rats, refutes the ideas that interdigitating cells differentiate from macrophages under immune stimulation or T cell influences. Follicular dendritic cells are more clearly visualized and appear to be polynucleated after emptying the follicles of lymphoid cells by irradiation. Follicular dendritic cells and tingible body macrophages are found in conventionally raised euthymic and athymic rats, but not in germ-free rats. The interrelationships of these and other types of non-lymphoid cells are discussed.