Correlation between overexpression of transforming growth factor-beta 1 in occluded fallopian tubes and postsurgical pregnancy among infertile women
Correlation between overexpression of transforming growth factor-beta 1 in occluded fallopian tubes and postsurgical pregnancy among infertile women
复制标题
不孕女性输卵管闭塞转化生长因子-β1过度表达与术后妊娠的相关性
DOI：
10.1016/j.ijgo.2010.07.016
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发表时间：
2011-01-01
影响因子：
3.8
通讯作者：
Zhang, Dan
中科院分区：
文献类型：
--
作者：
Li, Zhengyu;Sun, Ying;Zhang, Dan
目的：比较输卵管阻塞不孕妇女与对照组输卵管组织中转化生长因子β 1（TGF-β 1）及其受体的表达情况，探讨其与术后妊娠结局的关系。研究方法：采用免疫组织化学方法比较了60例输卵管粘连不孕患者和60例正常输卵管对照患者的TGF-β 1、TGF-β 1 R1和TGF-β 1 R2在阻塞输卵管中的表达谱;在2年随访时评估了与术后生育能力的潜在相关性。结果如下：输卵管粘连患者的TGF-β 1、TGF-β 1 R1和TG β 1 R2的免疫染色均显著高于正常标本（P
Objective: To compare the expression profiles of transforming growth factor-beta 1 (TGF-beta 1) and its receptors in occluded tubes of infertile women with those of control patients and to evaluate the potential correlation with postsurgical pregnancy outcome. Methods: The expression profiles of TGF-beta 1, TGF-beta 1R1, and TGF-beta 1R2 in occluded fallopian tubes were compared using immunohistochemistry between 60 infertile patients with adhered tubes and 60 control patients with normal tubes; potential correlations with postsurgical fertility were evaluated at 2-year follow up. Results: Immunostainings of TGF-beta 1, TGF-beta 1R1, and TG beta 1R2 were all significantly elevated in patients with adhered tubes compared with normal specimens (P