Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects
Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects
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DOI：
10.1016/j.neurobiolaging.2006.03.005
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发表时间：
2007-05-01
影响因子：
4.2
通讯作者：
Czeisler, Charles A.
中科院分区：
文献类型：
--
作者：
Duffy, Jeanne F.;Zeitzer, Jamie M.;Czeisler, Charles A.
衰老与睡眠时间和昼夜节律之间的关系发生变化有关，因此与睡眠有关的节律比年轻人发生得晚。为了研究对夜晚光线的相位延迟反应的差异是否与此有关，我们对10名健康老年人（>= 65岁）进行了为期9天的住院研究。我们在一个固定的程序中评估昼夜节律，在生物学的早期夜晚开始，将每个受试者暴露在6.5小时的广谱光刺激下，并重新评估昼夜节律。刺激范围从非常暗淡（类似于21倍）到非常明亮（类似于8000倍）的室内光。我们发现在照度和褪黑激素节律的相移之间存在显著的剂量-反应关系，有证据表明，对光的敏感度不同于年轻人，而不是对光的最大反应。这些发现表明，对中等光照水平的相位延迟反应与年龄有关。然而，我们的发现本身并不能解释与衰老相关的睡眠和昼夜节律之间的阶段关系改变。(c) 2006爱思唯尔公司版权所有。
Aging is associated with a change in the relationship between the timing of sleep and circadian rhythms, such that the rhythms occur later with respect to sleep than in younger adults. To investigate whether a difference in the phase-delaying response to evening light contributes to this, we conducted a 9-day inpatient study in 10 healthy older (>= 65 y.o.) subjects. We assessed circadian phase in a constant routine, exposed each subject to a 6.5 h broad-spectrum light stimulus beginning in the early biological night, and reassessed circadian phase. The stimuli spanned a range from very dim (similar to 21x) to very bright (similar to 8000 lx) indoor light. We found a significant dose-response relationship between illuminance and the phase shift of the melatonin rhythm, with evidence that sensitivity, but not the maximal response to light, differed from that of younger adults. These findings suggest an age-related reduction in the phase-delaying response to moderate light levels. However, our findings alone do not explain the altered phase relationship between sleep and circadian rhythms associated with aging. (c) 2006 Elsevier Inc. All rights reserved.