Tumor necrosis factor (TNF) biology and cell death
Tumor necrosis factor (TNF) biology and cell death
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DOI：
10.2741/2881
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Mocellin, Simone
中科院分区：
文献类型：
--
作者：
Bertazza, Loris;Mocellin, Simone
肿瘤坏死因子（TNF）是第一个用于人类癌症治疗的细胞因子。然而，它在治疗癌症患者中的作用仍存在争议。该领域的大多数不确定性源于这样一种认识，即直接激活或间接影响TNF与其受体结合的途径最终会导致细胞存活方面非常不同的结果。在本文中，我们总结了该细胞因子的基本分子生物学方面。这样的基础是批判性地处理关于TNF、肿瘤生物学和抗癌治疗之间关系的有时相互冲突的临床前和临床发现的先决条件。尽管过去十年在这一领域取得了显著进展，但我们仍然不清楚细胞在TNF刺激后如何在生与死之间做出选择。了解这一机制不仅可以揭示tnf驱动的程序性细胞死亡的生理意义，还可以帮助研究人员最大限度地发挥这种细胞因子的抗癌潜力。
Tumor necrosis factor (TNF) was the first cytokine to be used in humans for cancer therapy. However, its role in the treatment of cancer patients is debated. Most uncertainties in this field stem from the knowledge that the pathways directly activated or indirectly affected upon TNF engagement with its receptors can ultimately lead to very different outcomes in terms of cell survival. In this article, we summarize the fundamental molecular biology aspects of this cytokine. Such a basis is a prerequisite to critically approach the sometimes conflicting preclinical and clinical findings regarding the relationship between TNF, tumor biology and anticancer therapy. Although the last decade has witnessed remarkable advances in this field, we still do not know in detail how cells choose between life and death after TNF stimulation. Understanding this mechanism will not only shed new light on the physiological significance of TNF-driven programmed cell death but also help investigators maximize the anticancer potential of this cytokine.