Efficacy of exercise for menopausal symptoms: a randomized controlled trial
Efficacy of exercise for menopausal symptoms: a randomized controlled trial
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DOI：
10.1097/gme.0b013e31829e4089
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发表时间：
2014-04-01
影响因子：
2.7
通讯作者：
Caan, Bette J.
中科院分区：
文献类型：
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作者：
Sternfeld, Barbara;Guthrie, Katherine A.;Caan, Bette J.
目的本研究旨在确定运动训练对缓解血管痉挛和其他绝经期症状的疗效。方法对围绝经期晚期和绝经后久坐不动的女性频繁血管痉挛症状（VMS）参加了一项随机对照试验，在三个地点进行：106名妇女随机运动和142名妇女随机日常活动。运动干预包括每周三次，持续12周的个人设施有氧运动训练。在基线和第6周和第12周，在每日日记中记录VMS频率和困扰。意向性治疗分析比较了VMS频率和困扰、睡眠症状变化的组间差异（失眠严重程度指数和匹兹堡睡眠质量指数），以及情绪结果在第12周结束时，运动组VMS频率的变化，（平均变化，-2.4 VMS/d; 95% CI，-3.0至-1.7）和VMS困扰（四分量表的平均变化，-0.5; 95%CI，-0.6至-0.4）与对照组无显著差异（-2.6 VMS/d; 95% CI，-3.2至-2.0; P = 0.43; -0.5分; 95% CI，-0.6至-0.4; P = 0.75）。运动组在失眠症状（P = 0.03）、主观睡眠质量（P = 0.01）和抑郁症状（P = 0.04）方面有更大的改善，但差异很小，当调整P值进行多重比较时，差异不具有统计学意义。结果是相似的，当考虑治疗依从women only.Conclusions这些研究结果提供了强有力的证据表明，12周的中等强度的有氧运动不减轻VMS，但可能会导致睡眠质量，失眠，抑郁症的中年久坐不动的妇女在小的改善。
Objective This study aims to determine the efficacy of exercise training for alleviating vasomotor and other menopausal symptoms.Methods Late perimenopausal and postmenopausal sedentary women with frequent vasomotor symptoms (VMS) participated in a randomized controlled trial conducted in three sites: 106 women randomized to exercise and 142 women randomized to usual activity. The exercise intervention consisted of individual facility-based aerobic exercise training three times per week for 12 weeks. VMS frequency and bother were recorded on daily diaries at baseline and on weeks 6 and 12. Intent-to-treat analyses compared between-group differences in changes in VMS frequency and bother, sleep symptoms (Insomnia Severity Index and Pittsburgh Sleep Quality Index), and mood (Patient Health Questionnaire-8 and Generalized Anxiety Disorder-7 questionnaire).Results At the end of week 12, changes in VMS frequency in the exercise group (mean change, -2.4 VMS/d; 95% CI, -3.0 to -1.7) and VMS bother (mean change on a four-point scale, -0.5; 95% CI, -0.6 to -0.4) were not significantly different from those in the control group (-2.6 VMS/d; 95% CI, -3.2 to -2.0; P = 0.43; -0.5 points; 95% CI, -0.6 to -0.4; P = 0.75). The exercise group reported greater improvement in insomnia symptoms (P = 0.03), subjective sleep quality (P = 0.01), and depressive symptoms (P = 0.04), but differences were small and not statistically significant when P values were adjusted for multiple comparisons. Results were similar when considering treatment-adherent women only.Conclusions These findings provide strong evidence that 12 weeks of moderate-intensity aerobic exercise do not alleviate VMS but may result in small improvements in sleep quality, insomnia, and depression in midlife sedentary women.