Assessing medication effects in the MTA study using neuropsychological outcomes
Assessing medication effects in the MTA study using neuropsychological outcomes
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DOI：
10.1111/j.1469-7610.2005.01469.x
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发表时间：
2006-05-01
影响因子：
7.6
通讯作者：
Wigal, T
中科院分区：
文献类型：
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作者：
Epstein, JN;Conners, CK;Wigal, T
背景：虽然越来越多的研究对注意缺陷/多动障碍(ADHD)儿童的反应时(RT)和反应时变异性进行了研究，但很少有研究考察兴奋剂药物对这些重要的神经心理结果指标的影响。方法：316名ADHD儿童参加多模式治疗研究(MTA)，在24个月评估点完成Conners连续操作测验(CPT)。结果测量包括标准CPT结果(例如，委托误差、平均命中反应时间(RT))和源自Ex-Gauss分布模型的RT指标(即，u、sigma和tau)。结果：分析显示，药物治疗对所有神经心理学结果指标均有显著影响。对前高斯结果测量的结果显示，刺激性药物使RT减慢并降低RT变异性。结论：这表明了包含能够准确模拟实际分布模式的分析策略的重要性，包括正向偏差。此外，研究结果与ADHD的几个理论模型有关。
Background: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. Methods: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). Results: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. Conclusions: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.