Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage.
Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage.
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前交叉韧带的结构和解剖学恢复与手术后1年的软骨损伤有关：愈合韧带的特性会影响软骨损伤。
DOI：
10.1177/2325967117723886
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发表时间：
2017-08
影响因子：
2.6
通讯作者：
Murray MM
中科院分区：
文献类型：
--
作者：
Kiapour AM;Fleming BC;Murray MM
前交叉韧带重建后关节活动异常与关节病有关。然而，移植物特性（即结构和解剖）与创伤后骨关节炎程度之间的关系尚未明确。(1)重建的移植物或修复的ACL的结构（拉伸）和解剖（面积和对线）特性与ACL手术后1年的总软骨损伤面积相关，（2）前后（AP）膝关节松弛的侧侧差异与术后1年的总软骨损伤面积相关。对照实验室研究。16只小型猪接受单侧ACL横断，并随机接受ACL重建或桥接增强ACL修复。术后1年，对ACL或移植物愈合的拉伸性能、横截面积和多平面对线、AP膝关节松弛和软骨损伤区域进行评估。在重建组中，标准化移植物屈服和最大失效载荷、横截面积、矢状面和冠状面仰角以及60°屈曲时AP膝关节松弛的侧侧差异与术后1年的总软骨损伤面积相关（R2> 0.5，P <0.04）。在修复组中，标准化ACL屈服载荷、线性刚度、横截面积、矢状面和冠状面仰角与总软骨损伤面积相关（R2> 0.5，P <0.05）。当韧带或移植物的结构和解剖特性以及AP松弛度值接近于对侧ACL完整膝关节时，在手术治疗的膝关节中观察到较小的软骨病变区域。与修复的移植物相比，重建的移植物具有明显更大的标准化横截面积和矢状面仰角（更垂直）（P <0.02）。ACL术后胫股软骨损伤的程度与重建膝关节中愈合骨或移植物的拉伸性能、横截面积和多平面对齐以及AP膝关节松弛度相关。这些数据强调了对新型ACL损伤治疗的需求，这种治疗可以将撕裂ACL的结构和解剖特性恢复到天然ACL的结构和解剖特性，以尽量减少早发性创伤后骨关节炎的风险。
Abnormal joint motion has been linked to joint arthrosis after anterior cruciate ligament (ACL) reconstruction. However, the relationships between the graft properties (ie, structural and anatomic) and extent of posttraumatic osteoarthritis are not well defined. (1) The structural (tensile) and anatomic (area and alignment) properties of the reconstructed graft or repaired ACL correlate with the total cartilage lesion area 1 year after ACL surgery, and (2) side-to-side differences in anterior-posterior (AP) knee laxity correlate with the total cartilage lesion area 1 year postoperatively. Controlled laboratory study. Sixteen minipigs underwent unilateral ACL transection and were randomly treated with ACL reconstruction or bridge-enhanced ACL repair. The tensile properties, cross-sectional area, and multiplanar alignment of the healing ACL or graft, AP knee laxity, and cartilage lesion areas were assessed 1 year after surgery. In the reconstructed group, the normalized graft yield and maximum failure loads, cross-sectional area, sagittal and coronal elevation angles, and side-to-side differences in AP knee laxity at 60° of flexion were associated with the total cartilage lesion area 1 year after surgery (R 2 > 0.5, P < .04). In the repaired group, normalized ACL yield load, linear stiffness, cross-sectional area, and the sagittal and coronal elevation angles were associated with the total cartilage lesion area (R 2 > 0.5, P < .05). Smaller cartilage lesion areas were observed in the surgically treated knees when the structural and anatomic properties of the ligament or graft and AP laxity values were closer to those of the contralateral ACL-intact knee. Reconstructed grafts had a significantly larger normalized cross-sectional area and sagittal elevation angle (more vertical) when compared with repaired ACLs (P < .02). The tensile properties, cross-sectional area, and multiplanar alignment of the healing ACLs or grafts and AP knee laxity in reconstructed knees were associated with the extent of tibiofemoral cartilage damage after ACL surgery. These data highlight the need for novel ACL injury treatments that can restore the structural and anatomic properties of the torn ACL to those of the native ACL in an effort to minimize the risk of early-onset posttraumatic osteoarthritis.
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DOI：
10.1097/01.blo.0000197079.26600.09
发表时间：
2006-01-01
影响因子：
4.2
作者：
Andriacchi, Thomas P.;Briant, Paul L.;Koo, Seungbum
通讯作者：
Koo, Seungbum
影响因子：
2.4
作者：
Andriacchi, TP;Dyrby, CO
通讯作者：
Dyrby, CO
DOI：
10.1053/jars.2003.50066
发表时间：
2003-03-01
影响因子：
4.7
作者：
Ayerza, MA;Múscolo, DL;Rondón, L
通讯作者：
Rondón, L
影响因子：
3.8
作者：
Dustmann, M.;Schmidt, T.;Scheffler, S. U.
通讯作者：
Scheffler, S. U.
影响因子：
3.8
作者：
Jansson, KA;Harilainen, A;Tallroth, K
通讯作者：
Tallroth, K