Regular Khat (Catha edulis) chewing is associated with elevated diastolic blood pressure among adults in Butajira, Ethiopia: A comparative study
Regular Khat (Catha edulis) chewing is associated with elevated diastolic blood pressure among adults in Butajira, Ethiopia: A comparative study
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DOI：
10.1186/1471-2458-10-390
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发表时间：
2010-07-02
影响因子：
4.5
通讯作者：
Tesfaye, Fikru
中科院分区：
文献类型：
--
作者：
Getahun, Workineh;Gedif, Teferi;Tesfaye, Fikru
背景资料：新鲜的叶和芽的卡塔植物（Catha edulis）含有卡西酮，安非他明样生物碱负责其药理作用。在实验研究中，咀嚼阿拉伯茶与血压和心率的短暂上升有关。很少有研究在人口水平上检查定期或频繁咀嚼阿拉伯茶对血压的影响。这项研究进行了检查定期咀嚼阿拉伯茶与血压adultes.Methods：我们比较了收缩压和舒张压的成年人35-65岁的人经常咀嚼阿拉伯茶在过去的五年中，那些从来没有咀嚼阿拉伯茶在同一时期。研究参与者是从埃塞俄比亚布塔吉拉区有目的地选择的城市和农村村庄招募的。比较组，咀嚼者（334）和非咀嚼者（330），通过使用筛选问卷进行挨家挨户访问，从普通人群中确定。他们的频率匹配的性别和年龄在五年的范围内。通过结构化访谈和身体测量，包括血压，体重和heights.Results收集数据：高血压的患病率是显着较高的咀嚼阿拉伯茶（13.4%）比非咀嚼阿拉伯茶（10.7%），比值比（OR）= 1.66（95%置信区间（CI）1.05，3.13）。咀嚼者（29.9%）比非咀嚼者（20.6%）有相当高比例的舒张压（> 80 mmHg）。平均（sd）舒张压明显高于嚼阿拉伯茶者[75.0（11.6）]比非嚼阿拉伯茶者[72.9（11.7）]，P < 0.05。同样，咀嚼阿拉伯茶者的平均（sd）心率[76.3（11.5）]显著高于非咀嚼者[73.9（12.6）]，P < 0.05。有两个groups.Conclusion之间的平均收缩压没有显着差异：经常咀嚼阿拉伯茶与平均舒张压升高，这是一致的外周血管收缩作用的卡西酮。经常咀嚼阿拉伯茶可能会对心血管系统产生持续影响，从而导致人群血压升高。
Background: Fresh leaves and buds of the Khat plant (Catha edulis) contain Cathinone, an amphetamine like alkaloid responsible for its pharmacological action. Chewing of Khat has been associated with a transient rise in blood pressure and heart rate in experimental studies. Few studies examined the effect of regular or frequent Khat chewing on blood pressure at the population level. This study was conducted to examine the association of regular Khat chewing with blood pressure among adults.Methods: We compared systolic and diastolic blood pressure of adults 35-65 years of age who reported regular chewing of Khat during the preceding five years to those who never chewed Khat during the same period. Study participants were recruited from purposively selected urban and rural villages of Butajira District in Ethiopia. The comparative groups, chewers (334) and non-chewers (330), were identified from among the general population through a house-to-house visit using a screening questionnaire. They were frequency-matched for sex and age within a five-year range. Data were collected through structured interviews and physical measurements including blood pressure, weight and height.Results: The prevalence of hypertension was significantly higher among Khat chewers (13.4%) than non-chewers (10.7%), odds ratio (OR) = 1.66 (95% confidence interval (CI) 1.05, 3.13). A considerably high proportion of chewers (29.9%) than non-chewers (20.6%) had sub-optimal diastolic blood pressure (> 80 mmHg). The mean (sd) diastolic blood pressure was significantly higher among Khat chewers [75.0 (11.6)] than non-chewers [72.9 (11.7)], P < 0.05. Similarly, Khat chewers had significantly higher mean (sd) heart rate [76.3 (11.5)] than non-chewers [73.9 (12.6)], P < 0.05. There was no significant difference in mean systolic blood pressure between the two groups.Conclusion: Regular chewing of Khat is associated with elevated mean diastolic blood pressure, which is consistent with the peripheral vasoconstrictor effect of Cathinone. Regular Khat chewing may have sustained effects on the cardiovascular system that can contribute to elevated blood pressure at the population level.