Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility.
Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility.
复制标题
DOI：
10.4252/wjsc.v6.i2.195
复制
发表时间：
2014-04-26
影响因子：
4.1
通讯作者：
He, Haiping
中科院分区：
文献类型：
--
作者：
Nagamura-Inoue, Tokiko;He, Haiping
人脐带（UC）是间充质干细胞（MSC）的一个有前途的来源。除了无痛采集过程和更快的自我更新等显着优势外，UC-MSC 还表现出分化为三个胚层、在受损组织或发炎区域积累、促进组织修复和调节免疫反应的能力。有多种方案和培养方法可用于从 UC 的各个区室中分离 MSC，例如沃顿氏胶、静脉、动脉、UC 内膜以及羊膜下和血管周围区域。在这篇综述中，我们简要介绍了 UC 的各个区室作为 MSC 的来源，并强调了 UC-MSC 在再生医学和免疫治疗中的潜在临床应用。
Human umbilical cord (UC) is a promising source of mesenchymal stem cells (MSCs). Apart from their prominent advantages, such as a painless collection procedure and faster self-renewal, UC-MSCs have shown the ability to differentiate into three germ layers, to accumulate in damaged tissue or inflamed regions, to promote tissue repair, and to modulate immune response. There are diverse protocols and culture methods for the isolation of MSCs from the various compartments of UC, such as Wharton's jelly, vein, arteries, UC lining and subamnion and perivascular regions. In this review, we give a brief introduction to various compartments of UC as a source of MSCs and emphasize the potential clinical utility of UC-MSCs for regenerative medicine and immunotherapy.