Baroreceptor reflex is suppressed in rats that develop hyperalgesia behavior after nerve injury
Baroreceptor reflex is suppressed in rats that develop hyperalgesia behavior after nerve injury
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DOI：
10.1016/j.pain.2009.07.040
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发表时间：
2009-12-05
期刊：
影响因子：
7.4
通讯作者：
Seagard, Jeanne
中科院分区：
文献类型：
--
作者：
Gemes, Geza;Rigaud, Marcel;Seagard, Jeanne
压力感受器反射在血压升高时通过减少交感神经活动和增加迷走神经活动来缓冲自主神经的变化，而在血压下降时则通过相反的作用。由于疼痛和自主神经功能之间存在多种双向相互作用，我们研究了脊髓神经结扎（SNL）后疼痛神经损伤对心率（HR）、血压（BP）的影响及其通过压力感受反射的调节。接受SNL的大鼠被分为两组，一组是痛觉过敏组，在用药片触摸足底点状伤害性刺激后，痛觉过敏组会持续抬起、摇晃和梳理足部，另一组在SNL后没有表现出这种痛觉过敏行为。与接受皮肤切开或假SNL的对照组大鼠相比，SNL对无约束大鼠静息血压无影响。然而，压力感受器增益的两项测试显示，只有在SNL后出现持续痛觉过敏的动物才会出现抑郁。在SNL后未发生痛觉过敏的动物在SNL前和后4天的HR均升高，HR变异性分析表明，在相同的时间间隔内，迷走神经对静息HR的控制减弱，交感迷走神经平衡升高。在人类患者中，其他研究表明，在高血压、充血性心力衰竭、心肌梗死和中风等情况下，钝化的压力感受器反射敏感性预示着不良的预后。如果在慢性神经性疼痛期间也发现压力感受器反射抑制，这可能对生存产生不利影响。由爱思唯尔B.V.代表国际疼痛研究协会出版。
The baroreceptor reflex buffers autonomic changes by decreasing sympathetic activity and increasing vagal activity in response to blood pressure elevations, and by the reverse actions when the blood pressure falls. Because of the many bidirectional interactions of pain and autonomic function, we investigated the effect of painful nerve injury by spinal nerve ligation (SNL) on heart rate (HR), blood pressure (BP) and their regulation by the baroreceptor reflex. Rats receiving SNL were separated into either a hyperalgesic group that developed sustained lifting, shaking and grooming of the foot after plantar punctate nociceptive stimulation by pill touch or a group of animals that failed to show this hyperalgesic behavior after SNL. SNL produced no effect on resting BP recorded telemetrically in unrestrained rats compared to control rats receiving either skin incision or sham SNL. However, two tests of baroreceptor gain showed depression only in animals that developed sustained hyperalgesia after SNL. The animals that failed to develop hyperalgesia after SNL were found to have elevations in HR both before and for the first 4 days after SNL, and HR variability analysis gave indications of decreased vagal control of resting HR and elevated sympatho-vagal balance at these same time intervals. In human patients, other research has shown that blunted baroreceptor reflex sensitivity predicts poor outcome during conditions such as hypertension, congestive heart failure, myocardial infarction, and stroke. If baroreceptor reflex suppression is also found in human subjects during chronic neuropathic pain, this may adversely affect survival. Published by Elsevier B.V. on behalf of International Association for the Study of Pain.