The Use of Systemic and Topical Fluoroquinolones
The Use of Systemic and Topical Fluoroquinolones
复制标题
DOI：
10.1542/peds.2016-2706
复制
发表时间：
2016-11-01
期刊：
影响因子：
8
通讯作者：
Schutze, Gordon E.
中科院分区：
文献类型：
--
作者：
Jackson, Mary Anne;Schutze, Gordon E.
氟喹诺酮类药物以及所有抗菌药物的适当处方实践至关重要，因为考虑到不断变化的耐药模式，确定了其他治疗适应症，并且氟喹诺酮类药物在儿童中的毒性特征已得到更好的定义。早期推荐的全身治疗仍然存在;本报告概述了氟喹诺酮类药物在某些感染治疗中的广泛应用。处方临床医生应了解与氟喹诺酮类药物相关的特定不良反应，其在儿童中的使用应继续限于治疗无安全有效替代方案的感染，或口服氟喹诺酮类药物治疗是肠外抗菌药物治疗的合理替代方案。
Appropriate prescribing practices for fluoroquinolones, as well as all antimicrobial agents, are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children has become better defined. Earlier recommendations for systemic therapy remain; expanded uses of fluoroquinolones for the treatment of certain infections are outlined in this report. Prescribing clinicians should be aware of specific adverse reactions associated with fluoroquinolones, and their use in children should continue to be limited to the treatment of infections for which no safe and effective alternative exists or in situations in which oral fluoroquinolone treatment represents a reasonable alternative to parenteral antimicrobial therapy.