Inter- and intra-specific genomic divergence in Drosophila montana shows evidence for cold adaptation
Inter- and intra-specific genomic divergence in Drosophila montana shows evidence for cold adaptation
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果蝇蒙大拿州的种间和种内基因组差异显示了冷适应的证据
DOI：
10.1101/282582
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Parker D
中科院分区：
文献类型：
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作者：
Parker D
作为生态专家的物种的基因组可能包含基因组适应其生态位的特征。然而，将与生态特异性相关的基因与其他选择来源和更随机的变化区分开来是一个挑战。在这里，我们描述的基因组果蝇蒙大拿州，这是最极端的冷适应果蝇物种已知的。我们使用分支测试，以确定在冷和温暖的适应物种之间的对比加速分歧的基因，并确定约250个基因，显示差异，可能是由较低的同义替换率在冷适应物种。我们还寻找证据之间的加速分歧D。montana和D. virilis，一个先前测序的相对，但没有找到强有力的证据，编码序列变异的分歧选择。趋异基因参与多种功能，包括表皮和嗅觉过程。最后，我们还重新测序了三个群体的D。从它的生态和地理范围来看。离群位点更可能被发现在X染色体上，有一个比预期更大的重叠群体离群值和那些基因之间的冷适应drosophilaspecies牵连，这意味着一些连续性的选择过程中，在这些不同的进化尺度。
The genomes of species that are ecological specialists will likely contain signatures of genomic adaptation to their niche. However, distinguishing genes related to ecological specialism from other sources of selection and more random changes is a challenge. Here, we describe the genome ofDrosophila montana, which is the most extremely cold-adaptedDrosophilaspecies known. We use branch tests to identify genes showing accelerated divergence in contrasts between cold- and warm-adapted species and identify about 250 genes that show differences, possibly driven by a lower synonymous substitution rate in cold-adapted species. We also look for evidence of accelerated divergence betweenD. montanaandD. virilis, a previously sequenced relative, but do not find strong evidence for divergent selection on coding sequence variation. Divergent genes are involved in a variety of functions, including cuticular and olfactory processes. Finally, we also resequenced three populations ofD. montanafrom across its ecological and geographic range. Outlier loci were more likely to be found on the X chromosome and there was a greater than expected overlap between population outliers and those genes implicated in cold adaptation betweenDrosophilaspecies, implying some continuity of selective process at these different evolutionary scales.