Alcohol and hepatocellular carcinoma: The effect of lifetime intake and hepatitis virus infections in men and women
Alcohol and hepatocellular carcinoma: The effect of lifetime intake and hepatitis virus infections in men and women
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DOI：
10.1093/aje/155.4.323
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发表时间：
2002-02-15
影响因子：
5
通讯作者：
Nardi, G
中科院分区：
文献类型：
--
作者：
Donato, F;Tagger, A;Nardi, G
作者分别研究了男性和女性饮酒与肝细胞癌（HCC）之间的剂量效应关系，并考虑了乙型肝炎和丙型肝炎病毒感染。他们招募了464名首次诊断为HCC的受试者（380名男性）作为病例，824名未患肝脏疾病的受试者（686名男性）作为对照；1995-2000年间，他们都在意大利北部的布雷西亚住院治疗。样条回归模型显示，随着酒精摄入量的增加，HCC的优势比呈稳定的线性增加，每天酒精摄入量为60克，男性和女性之间没有实质性差异。当考虑酒精摄入量时，饮酒的持续时间和开始饮酒的年龄对优势比没有影响。戒酒1-10年的前饮酒者患HCC的风险高于现在的饮酒者。即使在没有乙型或丙型肝炎病毒感染的情况下，饮酒的影响也很明显。此外，还发现饮酒与两种感染之间存在协同作用，每天饮酒者的每一种肝炎病毒感染的优势比增加了约两倍。
The authors investigated the dose-effect relation between alcohol drinking and hepatocellular carcinoma (HCC) in men and women separately, also considering hepatitis B and hepatitis C virus infections. They enrolled 464 subjects (380 men) with a first diagnosis of HCC as cases and 824 subjects (686 men) unaffected by hepatic diseases as controls; all were hospitalized in Brescia, northern Italy, in 1995-2000. Spline regression models showed a steady linear increase in the odds ratio of HCC for increasing alcohol intake, for values of >60 g of ethanol per day, with no substantial differences between men and women. Duration of drinking and age at start had no effect on the odds ratio when alcohol intake was considered. Former drinkers who had stopped 1-10 years previously had a higher risk of HCC than current drinkers did. The effect of alcohol drinking was evident even in the absence of hepatitis B or hepatitis C virus infection. In addition, a synergism between alcohol drinking and either infection was found, with approximately a twofold increase in the odds ratio for each hepatitis virus infection for drinkers of >60 g per day.