Two phases of aging separated by the Smurf transition as a public path to death.
Two phases of aging separated by the Smurf transition as a public path to death.
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DOI：
10.1038/srep23523
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发表时间：
2016-03-22
影响因子：
4.6
通讯作者：
Rera M
中科院分区：
文献类型：
--
作者：
Dambroise E;Monnier L;Ruisheng L;Aguilaniu H;Joly JS;Tricoire H;Rera M
衰老最明显的特征是个体死亡概率随时间的增加。这个终生的过程伴随着大量的分子和生理变化。尽管在过去几十年中已经鉴定出许多与衰老有关的基因，但其主导因素尚未确定。为了确定驱动衰老的过程，我们在过去几年中开发了一种检测方法，可以在同步的黑腹果蝇群体中识别生理上衰老的个体。这些人的肠道通透性随着年龄的增长而增加，死亡风险也很高。在这里，我们发现这种衰老的生理标志物在 3 种无脊椎动物 Drosophila mojavensis、Drosophila virilis、Caenorhabditis elegans 以及 1 种脊椎动物 Danio rerio 中保守。我们的研究结果表明，肠道屏障功能障碍可能是衰老过程中的一个重要事件，在许多物种中都存在，因此增加了智人也可能出现这种情况的可能性。
Aging’s most obvious characteristic is the time dependent increase of an individual’s probability to die. This lifelong process is accompanied by a large number of molecular and physiological changes. Although numerous genes involved in aging have been identified in the past decades its leading factors have yet to be determined. To identify the very processes driving aging we have developed in the past years an assay to identify physiologically old individuals in a synchronized population of Drosophila melanogaster. Those individuals show an age-dependent increase of intestinal permeability followed by a high risk of death. Here we show that this physiological marker of aging is conserved in 3 invertebrate species Drosophila mojavensis, Drosophila virilis, Caenorhabditis elegans as well as in 1 vertebrate species Danio rerio. Our findings suggest that intestinal barrier dysfunction may be an important event in the aging process conserved across a broad range of species, thus raising the possibility that it may also be the case in Homo sapiens.