Antiviral activity of berberine and related compounds against human cytomegalovirus
Antiviral activity of berberine and related compounds against human cytomegalovirus
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DOI：
10.1016/j.bmcl.2006.12.085
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发表时间：
2007-03-15
影响因子：
2.7
通讯作者：
Uesato, Shinichi
中科院分区：
文献类型：
--
作者：
Hayashi, Kyoko;Minoda, Kazuki;Uesato, Shinichi
使用空斑试验评估盐酸小檗碱（1）和结构相关化合物的抗人巨细胞病毒（HCMV）活性。1的抗HCMV活性（IC_（50）0.68 μ M）与更昔洛韦（GCV）的IC_（50）0.91 μ M相当。据推测，I抑制HCMV复制的作用机制与GCV不同; I会在病毒渗透到宿主细胞后和病毒DNA合成前干扰细胞内事件。(c)2007爱思唯尔有限公司保留所有权利。
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus ;(HCMV) activity using the plaque assay. The anti-HCMV activity (IC50 0.68 mu M) of 1 was equivalent to that (IC50 0.91 mu m) of ganciclovir (GCV). The mechanism of action by which I inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis. (c) 2007 Elsevier Ltd. All rights reserved.